glycopeptide resistance gene cluster VanM

Accession ARO:3000256
CARD Short NamevanM_cluster
DefinitionHomologous to vanA, contains a D-Ala-D-Lac ligase. The plasmid-located vanM gene cluster is inducible and confers high resistance to vancomycin and teicoplanin. Gene orientation: RSYHMX.
AMR Gene Familyglycopeptide resistance gene cluster
Drug Classglycopeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification8 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic vancomycin [Antibiotic]
+ confers_resistance_to_antibiotic teicoplanin [Antibiotic]
+ glycopeptide resistance gene cluster [AMR Gene Family]
Sub-Term(s)
6 ontology terms | Show
Publications

Xu X, et al. 2010. Antimicrob Agents Chemother 54(11): 4643-4647. vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. (PMID 20733041)

Resistomes

Prevalence of glycopeptide resistance gene cluster VanM among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: gene cluster meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
No prevalence data


Detection Models

Model Name: glycopeptide resistance gene cluster VanM

Model Description:

Regulatory: vanR gene in vanM clustervanS gene in vanM cluster

Core: vanMvanH gene in vanM clustervanX gene in vanM cluster

Accessory: vanY gene in vanM cluster

Curator Acknowledgements
Curator Description Most Recent Edit