Accession | ARO:3000256 |
CARD Short Name | vanM_cluster |
Definition | Homologous to vanA, contains a D-Ala-D-Lac ligase. The plasmid-located vanM gene cluster is inducible and confers high resistance to vancomycin and teicoplanin. Gene orientation: RSYHMX. |
AMR Gene Family | glycopeptide resistance gene cluster |
Drug Class | glycopeptide antibiotic |
Resistance Mechanism | antibiotic target alteration |
Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic target alteration [Resistance Mechanism] + restructuring of bacterial cell wall conferring antibiotic resistance + glycopeptide antibiotic [Drug Class] + antibiotic resistance gene cluster, cassette, or operon |
Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic vancomycin [Antibiotic] + confers_resistance_to_antibiotic teicoplanin [Antibiotic] + glycopeptide resistance gene cluster [AMR Gene Family] |
Sub-Term(s) | 6 ontology terms | Show + vanH gene in vanM cluster part_of + vanM part_of + vanR gene in vanM cluster part_of + vanS gene in vanM cluster part_of + vanX gene in vanM cluster part_of + vanY gene in vanM cluster part_of |
Publications | Xu X, et al. 2010. Antimicrob Agents Chemother 54(11): 4643-4647. vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. (PMID 20733041) |
Prevalence of glycopeptide resistance gene cluster VanM among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI | GRDI-AMR2 |
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No prevalence data | |||||
Model Name: glycopeptide resistance gene cluster VanM
Model Description:
Regulatory: vanR gene in vanM clustervanS gene in vanM cluster
Core: vanMvanH gene in vanM clustervanX gene in vanM cluster
Accessory: vanY gene in vanM cluster
Curator | Description | Most Recent Edit |
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