vanH gene in vanM cluster

Accession ARO:3002947
Synonym(s)vanH-M vanHM
CARD Short NamevanH_in_vanM_cl
DefinitionAlso known as vanHM, is a vanH variant in the vanM gene cluster.
AMR Gene Familyglycopeptide resistance gene cluster, vanH
Drug Classglycopeptide antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Perfect MatchesEnterococcus faeciumg+p+wgs+gi, Klebsiella pneumoniaewgs, Klebsiella quasipneumoniaewgs
Resistomes with Sequence VariantsClostridium botulinumg+wgs, Clostridium sporogenesg+wgs, Enterococcus faeciumg+p+wgs+gi, Klebsiella pneumoniaewgs, Klebsiella quasipneumoniaewgs
Classification13 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ vanH [AMR Gene Family]
+ part_of glycopeptide resistance gene cluster VanM
Publications

Xu X, et al. 2010. Antimicrob Agents Chemother 54(11): 4643-4647. vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. (PMID 20733041)

Resistomes

Prevalence of vanH gene in vanM cluster among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Clostridium botulinum79.1%0%60.05%0%0%
Clostridium sporogenes100%0%100%0%0%
Enterococcus faecium0.32%0.26%0.34%1.96%0%
Klebsiella pneumoniae0%0%0.14%0%0%
Klebsiella quasipneumoniae0%0%0.13%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 200


>gb|ACL82960.1|+|vanH gene in vanM cluster [Enterococcus faecium]
MVLVMKDIGITIYGSEQDEADVFQEISSRFGVTPTIVSSPISETNVMLAPKNKCISVGHKSEIHKSILIALKESGVKYISTRSIGYNHID
MKAAEKMGIAVENVTYSPDSVADYTLMLILMAIRHTKSTLCSMEKHDFRLNSVRGKVLRDLTVGVLGTGHIGKAVIERLQGFGGHVLAYG
NNKEATANYVSFNELLQKSDILTIHVPLSDDTYHMIGHEQIKAMKQGAFLINTARGGLIDTEVLVKALEDGKLGGAALDVLEGEEGLFYF
DCTQKPINNQFLLKLQRMPNVTITPHTAYYSEKTLRDTVEKTVKNCLEFERRETHE


>gb|FJ349556.1|+|3884-4864|vanH gene in vanM cluster [Enterococcus faecium]
ATGGTCTTAGTAATGAAAGATATCGGCATTACCATTTATGGATCTGAGCAGGATGAGGCTGATGTGTTCCAGGAAATTTCATCTCGATTT
GGCGTTACACCTACCATTGTAAGCTCTCCTATATCAGAAACCAACGTAATGTTAGCCCCTAAAAATAAGTGTATCAGCGTGGGGCACAAG
TCTGAGATTCACAAATCTATCCTTATTGCATTGAAGGAATCCGGCGTCAAATATATCTCTACTCGAAGTATTGGTTACAATCATATAGAT
ATGAAGGCAGCGGAAAAAATGGGTATTGCTGTCGAGAACGTCACTTATTCACCAGATAGTGTTGCCGATTATACATTGATGCTGATACTT
ATGGCAATACGCCATACGAAATCTACTTTGTGCTCTATGGAAAAACATGATTTCAGACTGAACAGCGTCCGTGGTAAAGTACTGCGTGAC
CTGACAGTAGGTGTACTGGGAACCGGTCATATAGGCAAAGCGGTTATTGAGCGACTACAGGGGTTTGGAGGTCACGTGTTGGCGTACGGC
AACAACAAAGAGGCGACGGCAAATTATGTATCCTTCAATGAATTACTGCAAAAAAGTGACATTCTAACCATTCATGTACCCCTTAGCGAT
GACACATACCATATGATCGGTCACGAACAGATTAAAGCAATGAAACAGGGCGCCTTTCTTATTAATACTGCTCGAGGTGGACTTATAGAT
ACCGAAGTTCTGGTTAAAGCACTGGAGGACGGAAAACTGGGGGGCGCCGCATTAGATGTATTAGAGGGAGAAGAAGGGCTTTTCTACTTT
GATTGCACCCAAAAGCCAATTAACAATCAATTTTTGCTGAAACTTCAAAGGATGCCAAATGTGACAATCACACCGCATACGGCTTACTAT
AGCGAAAAAACGTTACGTGATACTGTTGAAAAAACAGTCAAGAACTGTTTGGAATTTGAGAGGAGAGAGACACATGAATAG

Curator Acknowledgements
Curator Description Most Recent Edit