vanH [AMR Gene Family]

Accession ARO:3000006
DefinitionVanH is a D-specific alpha-ketoacid dehydrogenase that synthesizes D-lactate. D-lactate is incorporated into the end of the peptidoglycan subunits, decreasing vancomycin binding affinity.
Drug Classglycopeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Sub-Term(s)
7 ontology terms | Show
Publications

Marshall CG, et al. 1997. Proc Natl Acad Sci U S A 94(12): 6480-6483. D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB. (PMID 9177243)

Bugg TD, et al. 1991. Biochemistry 30(43): 10408-10415. Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. (PMID 1931965)