balhimycin [Antibiotic]

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Accession ARO:3000120
DefinitionBalhimycin is a vancomycin-like glycopeptide antibiotic produced by Amycolatopsis balhimycina. It binds to the terminal Lys-D-Ala-D-Ala of peptidoglycan precursors.
Drug Classglycopeptide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
1 ontology terms | Show
+ acyl-D-alanyl-D-alanine targeted_by_antibiotic

Stegmann E, et al. 2006. J Biotechnol 124(4): 640-653. Genetic analysis of the balhimycin (vancomycin-type) oxygenase genes. (PMID 16730832)

Pelzer S, et al. 1999. Antimicrob Agents Chemother 43(7): 1565-1573. Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908. (PMID 10390204)

Pfeifer V, et al. 2001. J Biol Chem 276(42): 38370-38377. A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine. (PMID 11495926)

Schafer M, et al. 1998. Acta Crystallogr D Biol Crystallogr 54(PT 2): 175-183. Structure of balhimycin and its complex with solvent molecules. (PMID 9761883)

Recktenwald J, et al. 2002. Microbiology 148(PT 4): 1105-1118. Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules. (PMID 11932455)