murG transferase [AMR Gene Family]

Accession ARO:3004560
DefinitionmurG acetylglucosaminyltransferase enzymes inhibited by vancomycin. Mutations in murG confer resistance to vancomycin through antibiotic target alteration.
Drug Classglycopeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ antibiotic resistant gene variant or mutant
+ confers_resistance_to_antibiotic vancomycin [Antibiotic]
+ confers_resistance_to_drug_class glycopeptide antibiotic [Drug Class]
1 ontology terms | Show

Leeds JA, et al. 2014. J. Antimicrob. Chemother. 69(1):41-4 In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin. (PMID 23887866)