vanY [AMR Gene Family]

Accession ARO:3000077
DefinitionVanY is a D,D-carboxypeptidase that cleaves removes the terminal D-Ala from peptidoglycan for the addition of D-Lactate. The D-Ala-D-Lac peptidoglycan subunits have reduced binding affinity with vancomycin compared to D-Ala-D-Ala.
Drug Classglycopeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Sub-Term(s)
6 ontology terms | Show
Publications

Meziane-Cherif D, et al. 2014. Proc Natl Acad Sci U S A 111(16): 5872-5877. Structural basis for the evolution of vancomycin resistance D,D-peptidases. (PMID 24711382)

Courvalin P. 2005. Clin Infect Dis 42(SUPPL 1): S25-S34. Vancomycin resistance in gram-positive cocci. (PMID 16323116)

Curator Acknowledgements
Curator Description Most Recent Edit