vanXY [AMR Gene Family]

Accession ARO:3000496
DefinitionVanXY is a protein with both D,D-carboxypeptidase and D,D-dipeptidase activity, found in Enterococcus gallinarum. It cleaves and removes the terminal D-Ala of peptidoglycan subunits for the incorporation of D-Ser by VanC. D-Ala-D-Ser has low binding affinity with vancomycin.
Drug Classglycopeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
5 ontology terms | Show

Reynolds PE, et al. 1999. Mol Microbiol 34(2): 341-349. Gene vanXYC encodes D,D -dipeptidase (VanX) and D,D-carboxypeptidase (VanY) activities in vancomycin-resistant Enterococcus gallinarum BM4174. (PMID 10564477)