vanXY gene in vanE cluster

Accession ARO:3002967
Synonym(s)vanXY-E vanXYE
CARD Short NamevanXY_in_vanE
DefinitionAlso known as vanXY, is a vanXY variant found in the vanE gene cluster.
AMR Gene Familyglycopeptide resistance gene cluster, vanXY
Drug Classglycopeptide antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Perfect MatchesEnterococcus faecaliswgs
Resistomes with Sequence VariantsAcinetobacter baumanniiwgs, Enterococcus faecaliswgs, Enterococcus pallenswgs
Classification12 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ part_of glycopeptide resistance gene cluster VanE
+ vanXY [AMR Gene Family]
Publications

Boyd DA, et al. 2002. Antimicrob Agents Chemother 46(6): 1977-1979. Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada. (PMID 12019119)

Resistomes

Prevalence of vanXY gene in vanE cluster among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Acinetobacter baumannii0%0%0.01%0%0%
Enterococcus faecalis0%0%0.08%0%0%
Enterococcus pallens0%0%100%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 125


>gb|AAL27443.1|+|vanXY gene in vanE cluster [Enterococcus faecalis]
MKKNYLRLINENNEIKDSERPSHLVQAPFAQTNILVDPMVAIQLEKLIKTTGLDSQIITIDGYRSKETQQALWDETIQEKGLEFAHKYVA
KPGCSEHEIGLAVDLGLATKENDFIRPSFTDSPIVDKFLKHMTDFGFILRYQKGKESITNINYEPWHFRYVGTPHSSIMVQQNWVLEEYI
EFIESIRGTAYEA


>gb|FJ872411.1|+|40766-41347|vanXY gene in vanE cluster [Enterococcus faecalis]
ATGAAAAAAAATTATCTACGATTGATTAATGAAAACAATGAAATAAAAGACTCTGAGAGACCAAGTCACCTTGTTCAGGCTCCGTTTGCA
CAAACAAATATACTAGTTGATCCTATGGTAGCGATACAGCTAGAAAAACTAATAAAGACAACAGGTCTTGATAGCCAAATTATTACCATT
GATGGCTATCGTTCAAAGGAGACACAGCAAGCACTTTGGGATGAGACGATTCAAGAAAAAGGGCTTGAATTTGCGCACAAATATGTGGCA
AAGCCTGGATGTAGTGAACATGAAATTGGTTTAGCAGTGGATTTGGGGTTAGCTACGAAAGAAAATGATTTTATTCGCCCAAGTTTCACT
GATAGTCCGATTGTTGATAAATTTTTAAAGCATATGACAGATTTCGGCTTTATCTTAAGATATCAAAAAGGAAAAGAATCTATTACCAAT
ATAAACTATGAACCATGGCATTTCAGGTATGTAGGGACACCCCATAGTTCGATTATGGTACAGCAAAACTGGGTATTAGAAGAATACATT
GAATTCATTGAGTCAATAAGAGGAACTGCTTATGAAGCATAG

Curator Acknowledgements
Curator Description Most Recent Edit