| Accession | ARO:3000259 |
| CARD Short Name | vanE_cluster |
| Definition | Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanE gene cluster is inducible and confers low resistance to vancomycin. vanE organisms remain susceptible to teicoplanin. Gene orientation: E(XY)TRS. |
| AMR Gene Family | glycopeptide resistance gene cluster |
| Drug Class | glycopeptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic target alteration [Resistance Mechanism] + restructuring of bacterial cell wall conferring antibiotic resistance + glycopeptide antibiotic [Drug Class] + antibiotic resistance gene cluster, cassette, or operon |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic vancomycin [Antibiotic] + glycopeptide resistance gene cluster [AMR Gene Family] |
| Sub-Term(s) | 5 ontology terms | Show + vanE part_of + vanR gene in vanE cluster part_of + vanS gene in vanE cluster part_of + vanT gene in vanE cluster part_of + vanXY gene in vanE cluster part_of |
| Publications | Fines M, et al. 1999. Antimicrob Agents Chemother 43(9): 2161-2164. VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405. (PMID 10471558) Abadia Patino L, et al. 2002. J Bacteriol 184(23): 6457-6464. vanE gene cluster of vancomycin-resistant Enterococcus faecalis BM4405. (PMID 12426332) Boyd DA, et al. 2002. Antimicrob Agents Chemother 46(6): 1977-1979. Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada. (PMID 12019119) Courvalin P. 2005. Clin Infect Dis 42(SUPPL 1): S25-S34. Vancomycin resistance in gram-positive cocci. (PMID 16323116) |
Prevalence of glycopeptide resistance gene cluster VanE among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Name: glycopeptide resistance gene cluster VanE
Model Description:
Regulatory: vanR gene in vanE clustervanS gene in vanE cluster
Core: vanEvanXY gene in vanE clustervanT gene in vanE cluster