Accession | ARO:3000011 |
Definition | VanX is a D,D-dipeptidase that cleaves D-Ala-D-Ala but not D-Ala-D-Lac, ensuring that the latter dipeptide that has reduced binding affinity with vancomycin is used to synthesize peptidoglycan substrate. |
Drug Class | glycopeptide antibiotic |
Resistance Mechanism | antibiotic target alteration |
Classification | 7 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + restructuring of bacterial cell wall conferring antibiotic resistance + determinant of antibiotic resistance + protein(s) conferring antibiotic resistance via molecular bypass + antibiotic molecule |
Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_drug_class glycopeptide antibiotic [Drug Class] + gene(s) or protein(s) associated with a glycopeptide resistance cluster |
Sub-Term(s) | 8 ontology terms | Show |
Publications | Reynolds PE, et al. 1994. Mol Microbiol 13(6): 1065-1070. Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine. (PMID 7854121) |
Curator | Description | Most Recent Edit |
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