| Accession | ARO:3005036 |
| CARD Short Name | BLMT |
| Definition | BLMT is a bleomycin (Bm) resistance protein, encoded by the ble gene on the transposon Tn5. This protein confers a survival advantage to Escherichia coli host cells. BLMT confers resistance to bleomycin. |
| AMR Gene Family | Bleomycin resistant protein |
| Drug Class | glycopeptide antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter lwoffiiwgs, Aeromonas caviaewgs, Burkholderia multivoranswgs, Enterobacter hormaecheiwgs, Escherichia coliwgs, Klebsiella pneumoniaewgs, Pseudomonas aeruginosag+wgs, Pseudomonas putidawgs, Salmonella entericawgs, Shigella sonneiwgs |
| Resistomes with Sequence Variants | Acinetobacter lwoffiiwgs, Aeromonas caviaewgs, Burkholderia glumaeg, Burkholderia multivoranswgs, Enterobacter hormaecheiwgs, Escherichia coliwgs, Klebsiella pneumoniaewgs, Phocaeicola doreiwgs, Pseudomonas aeruginosag+p+wgs, Pseudomonas putidawgs, Salmonella entericawgs, Shigella sonneiwgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + glycopeptide antibiotic [Drug Class] + gene involved in antibiotic sequestration + antibiotic mixture |
| Parent Term(s) | 2 ontology terms | Show + Bleomycin resistant protein [AMR Gene Family] + confers_resistance_to_antibiotic bleomycin [Antibiotic] |
| Publications | Kumagai T, et al. 1999. FEBS Lett 442(1):34-8 Characterization of the bleomycin resistance determinant encoded on the transposon Tn5. (PMID 9923599) |
Prevalence of BLMT among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter lwoffii | 0% | 0% | 2.63% | 0% |
| Aeromonas caviae | 0% | 0% | 0.54% | 0% |
| Burkholderia glumae | 1% | 0% | 0% | 0% |
| Burkholderia multivorans | 0% | 0% | 0.24% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.04% | 0% |
| Escherichia coli | 0% | 0% | 0.29% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.02% | 0% |
| Phocaeicola dorei | 0% | 0% | 1.04% | 0% |
| Pseudomonas aeruginosa | 0.61% | 0.29% | 0.48% | 0% |
| Pseudomonas putida | 0% | 0% | 0.53% | 0% |
| Salmonella enterica | 0% | 0% | 0.52% | 0% |
| Shigella sonnei | 0% | 0% | 0.15% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 200