| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3000738 |
| Synonym(s) | DNA |
| Definition | Antibiotics can target DNA to cause strand breaks or prevent transcription. The activity of these antibiotics can be context dependent: some antibiotics are converted to an active form only in certain species, while others target DNA as it is being transcribed. |
| Drug Class | peptide antibiotic, nonribosomal peptide antibiotics, glycopeptide antibiotic, nitrofuran antibiotic |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + peptide antibiotic [Drug Class] + nonribosomal peptide antibiotics [Drug Class] + antibiotic mixture + glycopeptide antibiotic [Drug Class] + nitrofuran antibiotic [Drug Class] + antibiotic target + bleomycin [Antibiotic] |
| Parent Term(s) | 6 ontology terms | Show + targeted_by_antibiotic bleomycin [Antibiotic] + targeted_by_antibiotic nitrofurantoin [Antibiotic] + targeted_by_antibiotic bleomycinic acid [Antibiotic] + targeted_by_antibiotic bleomycin A2 [Antibiotic] + targeted_by_antibiotic bleomycin B2 [Antibiotic] + nucleic acid targeted by antibiotic |
| Sub-Term(s) | 2 ontology terms | Show |
| Publications | Muller WE and Zahn RK. 1977. Prog Biochem Pharmacol 11: 28-47. Effect of bleomycin on DNA, RNA, protein, chromatin and on cell transformation by oncogenic RNA viruses. (PMID 63969) Chen J and Stubbe J. 2005. Nat Rev Cancer 5(2): 102-112. Bleomycins: towards better therapeutics. (PMID 15685195) McCalla DR, et al. 1971. Cancer Res 31(12): 2184-2188. Breakage of bacterial DNA by nitrofuran derivatives. (PMID 4941089) |
| Curator | Description | Most Recent Edit |
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