deoxyribonucleic acid

Accession ARO:3000738
DefinitionAntibiotics can target DNA to cause strand breaks or prevent transcription. The activity of these antibiotics can be context dependent: some antibiotics are converted to an active form only in certain species, while others target DNA as it is being transcribed.
Classification2 ontology terms | Show
Parent Term(s)6 ontology terms | Show
+ nucleic acid targeted by antibiotic
+ targeted_by_antibiotic bleomycin A2 [Antibiotic]
+ targeted_by_antibiotic bleomycin B2 [Antibiotic]
+ targeted_by_antibiotic bleomycinic acid [Antibiotic]
+ targeted_by_antibiotic nitrofurantoin [Antibiotic]
+ targeted_by_antibiotic bleomycin [Antibiotic]
2 ontology terms | Show

Muller WE and Zahn RK. 1977. Prog Biochem Pharmacol 11: 28-47. Effect of bleomycin on DNA, RNA, protein, chromatin and on cell transformation by oncogenic RNA viruses. (PMID 63969)

Chen J and Stubbe J. 2005. Nat Rev Cancer 5(2): 102-112. Bleomycins: towards better therapeutics. (PMID 15685195)

McCalla DR, et al. 1971. Cancer Res 31(12): 2184-2188. Breakage of bacterial DNA by nitrofuran derivatives. (PMID 4941089)