anaerobe DNA

Accession ARO:3000742
DefinitionDNA in anaerobes are targeted by antibiotics that are converted to an active form in the anaerobe environment. For nitroimidazoles, the antibiotic is reduced to a highly oxidative intermediate that causes DNA oxidation and double-stranded breaks.
Classification3 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ targeted_by_antibiotic metronidazole [Antibiotic]
+ deoxyribonucleic acid

Edwards DI. 1993. J Antimicrob Chemother 31(1): 9-20. Nitroimidazole drugs--action and resistance mechanisms. I. Mechanisms of action. (PMID 8444678)