metronidazole [Antibiotic]

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Accession ARO:3000689
Synonym(s)Flagyl metronidazol
DefinitionMetronidazole is a nitroimidazole that is active against anaerobic bacteria and protozoa. It is not effective against aerobic bacteria. Nitroimidazoles act by oxidizing DNA causing strand breaks and cell death.
Drug Classnitroimidazole antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
19 ontology terms | Show
+ anaerobe DNA targeted_by_antibiotic
+ msbA confers_resistance_to_antibiotic
+ hp1181 confers_resistance_to_antibiotic
+ hp1184 confers_resistance_to_antibiotic
+ Antibiotic resistant Helicobacter pylori nitroreductase [AMR Gene Family] confers_resistance_to_antibiotic
+ Helicobacter pylori frxA mutation conferring resistance to metronidazole confers_resistance_to_antibiotic
+ Helicobacter pylori rdxA mutation conferring resistance to metronidazole confers_resistance_to_antibiotic
+ nimA confers_resistance_to_antibiotic
+ nimC confers_resistance_to_antibiotic
+ nimD confers_resistance_to_antibiotic
+ nimE confers_resistance_to_antibiotic
+ nimH confers_resistance_to_antibiotic
+ nimI confers_resistance_to_antibiotic
+ nimJ confers_resistance_to_antibiotic
+ nimK confers_resistance_to_antibiotic
+ nimB confers_resistance_to_antibiotic
+ nimG confers_resistance_to_antibiotic
+ Clostridioides difficile nimB confers_resistance_to_antibiotic
+ nimF confers_resistance_to_antibiotic

Edwards DI. 1993. J Antimicrob Chemother 31(1): 9-20. Nitroimidazole drugs--action and resistance mechanisms. I. Mechanisms of action. (PMID 8444678)