metronidazole [Antibiotic]

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Accession ARO:3000689
Synonym(s)metronidazol Flagyl
DefinitionMetronidazole is a nitroimidazole that is active against anaerobic bacteria and protozoa. It is not effective against aerobic bacteria. Nitroimidazoles act by oxidizing DNA causing strand breaks and cell death.
Drug Classnitroimidazole antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
4 ontology terms | Show
+ anaerobe DNA targeted_by_antibiotic
+ msbA confers_resistance_to_antibiotic
+ hp1181 confers_resistance_to_antibiotic
+ hp1184 confers_resistance_to_antibiotic
Publications

Edwards DI. 1993. J Antimicrob Chemother 31(1): 9-20. Nitroimidazole drugs--action and resistance mechanisms. I. Mechanisms of action. (PMID 8444678)