Antibiotic resistant Helicobacter pylori nitroreductase [AMR Gene Family]

Accession ARO:3007056
DefinitionInactivation of the oxygen-insensitive NADPH nitroreductases in Helicobacter pylori play a role in metronidazole resistance.
Drug Classnitroimidazole antibiotic
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ antibiotic resistant gene variant or mutant
+ confers_resistance_to_antibiotic metronidazole [Antibiotic]
+ confers_resistance_to_drug_class nitroimidazole antibiotic [Drug Class]
2 ontology terms | Show

Jeong JY, et al. 2001. J Bacteriol 183(17):5155-62 Roles of FrxA and RdxA nitroreductases of Helicobacter pylori in susceptibility and resistance to metronidazole. (PMID 11489869)