| Accession | ARO:3007104 |
| CARD Short Name | nimA |
| Definition | nimA is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. |
| AMR Gene Family | nitroimidazole reductase |
| Drug Class | nitroimidazole antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Bacteroides fragilisp+wgs, Eikenella corrodensg+wgs, Enterocloster clostridioformisg+wgs, Faecalibacterium prausnitziiwgs |
| Classification | 7 ontology terms | Show |
| Parent Term(s) | 2 ontology terms | Show + nitroimidazole reductase [AMR Gene Family] + confers_resistance_to_antibiotic metronidazole [Antibiotic] |
| Publications | Haggoud A, et al. 1994. Antimicrob. Agents Chemother. 38(5):1047-51 Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes. (PMID 8067736) Stubbs SL, et al. 2000. J Clin Microbiol 38(9):3209-13 PCR-restriction fragment length polymorphism analysis for identification of Bacteroides spp. and characterization of nitroimidazole resistance genes. (PMID 10970359) |
Prevalence of nimA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Bacteroides fragilis | 0% | 2.08% | 0.27% | 0% |
| Eikenella corrodens | 100% | 0% | 100% | 0% |
| Enterocloster clostridioformis | 100% | 0% | 25.58% | 0% |
| Faecalibacterium prausnitzii | 0% | 0% | 3.88% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 150