nitroimidazole reductase [AMR Gene Family]

Accession ARO:3007103
DefinitionNitroimidazole reductases are a group of enzymes that deactivate nitroimidazole antibiotics by reducing their nitro functional group to an amino group. These enzymes are associated with resistance to nitroimidazole derivatives in Bacteroides fragilis but have also been reported in a variety of anaerobic Gram-negative and Gram-positive genera. The minimum inhibitory concentrations for these enzymes vary greatly depending on species, strain, and precise nitroimidazole treatment used.
Drug Classnitroimidazole antibiotic
Resistance Mechanismantibiotic inactivation
Classification5 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ antibiotic inactivation enzyme
+ confers_resistance_to_drug_class nitroimidazole antibiotic [Drug Class]
12 ontology terms | Show

Alauzet C, et al. 2019. Anaerobe 55:40-53 Metronidazole resistance and nim genes in anaerobes: A review. (PMID 30316817)

Stubbs SL, et al. 2000. J Clin Microbiol 38(9):3209-13 PCR-restriction fragment length polymorphism analysis for identification of Bacteroides spp. and characterization of nitroimidazole resistance genes. (PMID 10970359)