Accession ARO:3003965
CARD Short Namehp1184
Definitionhp1184 is a translocase that belongs to the MATE efflux pump family. It is found in H. pylori and is involved in the active efflux of antibiotics.
AMR Gene Familymultidrug and toxic compound extrusion (MATE) transporter
Drug Classnitroimidazole antibiotic, tetracycline antibiotic, fluoroquinolone antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification10 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ multidrug and toxic compound extrusion (MATE) transporter [AMR Gene Family]
+ confers_resistance_to_antibiotic metronidazole [Antibiotic]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]

van Amsterdam K, et al. 2005. Antimicrob. Agents Chemother. 49(4):1477-82 A Helicobacter pylori TolC efflux pump confers resistance to metronidazole. (PMID 15793129)

Falsafi T, et al. 2016. Jundishapur J Microbiol 9(4):e30726 Association of hp1181 and hp1184 Genes With the Active Efflux Phenotype in Multidrug-Resistant Isolates of Helicobacter pylori. (PMID 27303615)

Private model - RGI is not currently using this model.