multidrug and toxic compound extrusion (MATE) transporter [AMR Gene Family]

Accession ARO:3000112
DefinitionDirected pumping of antibiotic out of a cell to confer resistance. Multidrug and toxic compound extrusion (MATE) transporters utilize the cationic gradient across the membrane as an energy source. Although there is a diverse substrate specificity, almost all MATE transporters recognize fluoroquinolones. Arciflavine, ethidium and aminoglycosides are also good substrates.
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
9 ontology terms | Show
+ mepA
+ abeM
+ MdtK
+ emeA
+ hmrM
+ hp1184
+ cdeA
+ PmpM
+ CrcB

Otsuka M, et al. 2005. Proc Natl Acad Sci U S A 102(50): 17923-17928. A human transporter protein that mediates the final excretion step for toxic organic cations. (PMID 16330770)

Kuroda T and Tsuchiya T. 2009. Biochim Biophys Acta 1794(5): 763-768. Multidrug efflux transporters in the MATE family. (PMID 19100867)