| Accession | ARO:3000112 |
| Definition | Directed pumping of antibiotic out of a cell to confer resistance. Multidrug and toxic compound extrusion (MATE) transporters utilize the cationic gradient across the membrane as an energy source. Although there is a diverse substrate specificity, almost all MATE transporters recognize fluoroquinolones. Arciflavine, ethidium and aminoglycosides are also good substrates. |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Classification | 4 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] |
| Sub-Term(s) | 9 ontology terms | Show |
| Publications | Otsuka M, et al. 2005. Proc Natl Acad Sci U S A 102(50): 17923-17928. A human transporter protein that mediates the final excretion step for toxic organic cations. (PMID 16330770) Kuroda T and Tsuchiya T. 2009. Biochim Biophys Acta 1794(5): 763-768. Multidrug efflux transporters in the MATE family. (PMID 19100867) |