multidrug and toxic compound extrusion (MATE) transporter [AMR Gene Family]

Accession ARO:3000112
DefinitionDirected pumping of antibiotic out of a cell to confer resistance. Multidrug and toxic compound extrusion (MATE) transporters utilize the cationic gradient across the membrane as an energy source. Although there is a diverse substrate specificity, almost all MATE transporters recognize fluoroquinolones. Arciflavine, ethidium and aminoglycosides are also good substrates.
Drug Classtetracycline antibiotic, fluoroquinolone antibiotic, glycylcycline, acridine dye
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification6 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ confers_resistance_to_drug_class glycylcycline [Drug Class]
+ confers_resistance_to_drug_class tetracycline antibiotic [Drug Class]
+ confers_resistance_to_drug_class acridine dye [Drug Class]
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
8 ontology terms | Show
+ mepA
+ abeM
+ MdtK
+ emeA
+ hmrM
+ hp1184
+ cdeA
+ PmpM

Otsuka M, et al. 2005. Proc Natl Acad Sci U S A 102(50): 17923-17928. A human transporter protein that mediates the final excretion step for toxic organic cations. (PMID 16330770)

Kuroda T and Tsuchiya T. 2009. Biochim Biophys Acta 1794(5): 763-768. Multidrug efflux transporters in the MATE family. (PMID 19100867)