MdtK

Accession ARO:3001327
Synonym(s)NorE YdhE norM
DefinitionA multidrug and toxic compound extrusions (MATE) transporter conferring resistance to norfloxacin, doxorubicin and acriflavine.
AMR Gene Familymultidrug and toxic compound extrusion (MATE) transporter
Drug Classtetracycline antibiotic, fluoroquinolone antibiotic, glycylcycline, acridine dye
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
ResistomesSalmonella entericag+wgs
Classification10 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ multidrug and toxic compound extrusion (MATE) transporter [AMR Gene Family]
Publications

Nishino K, et al. 2005. Mol Microbiol 59(1): 126-141. Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium. (PMID 16359323)

Resistomes

Prevalence of MdtK among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Listeria monocytogenes0%0%0.07%
Salmonella enterica98.06%0%98.62%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 900


>gb|AML99881.1|-|mdtK [Salmonella enterica subsp. enterica serovar Typhimurium]
MNVSTALRQAVVRTPWYAKRKSYKVLFWREITPLAIPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTV
VVAFSLGKRDRRRARAAARQSLVIMTLFAVVLAVVIHYFGSEIINIVAGEATPEVKGLALTYLELTVLSYPAAAIALIGSGALRGAGNTK
IPLMINGGMNILNIIISSILIYGAFSWQGLGFAGAGLGLTISRYIGAVAIIWVLMIGFNPALRIPLKSYLKPLNFGIIWEVMGIGIPASI
ESVLFNGSKLLTQMFVAGMGTNVIAGNFIAFSVAALINLPGNALGSASTIITGKRLGTGQIGQAERQLRHVFWMSTIVLTAIAWGTAPFA
GLFASFYTQEQDVKEVVKVLLWLNAAFMPIWAAAWVLPSGFKGARDVRFAMWVSMLGMWGCRVVAGYTLGIVLGMGVVGVWLGMFLDWAV
RGALFYWRLISGRWLWRYPRVKRE


>gb|CP014358.1|-|2161326-2162750|mdtK [Salmonella enterica subsp. enterica serovar Typhimurium]
TTGAACGTCTCCACTGCCTTACGCCAGGCTGTCGTCCGTACGCCCTGGTATGCCAAACGCAAGAGCTACAAAGTGTTGTTCTGGCGTGAA
ATCACCCCACTTGCTATCCCTATTTTTCTGGAAAATACCTGTGTTTTGCTAATGGGCGTGCTCAGTACTTTTCTCGTCAGTTGGCTGGGC
AAGGAAGCAATGGCGGGCGTGGGGCTTGCCGACAGTTTTAATATGGTAATTATGGCTTTTTTTGCGGCTATCGATCTTGGTACTACGGTG
GTGGTCGCCTTTAGCCTCGGCAAGCGCGACAGGCGACGCGCAAGGGCGGCGGCGCGCCAGTCGCTGGTGATTATGACGCTATTTGCCGTT
GTGCTGGCAGTGGTCATTCATTATTTCGGCAGTGAAATTATTAATATTGTCGCAGGCGAGGCGACGCCAGAAGTAAAGGGGCTGGCGTTA
ACGTACCTTGAACTGACGGTGCTGAGTTATCCGGCTGCGGCAATTGCGCTAATCGGTAGCGGCGCGCTGCGTGGGGCAGGGAATACGAAA
ATCCCGTTGATGATTAACGGCGGGATGAACATTCTCAATATTATTATCAGCAGCATCCTGATTTACGGGGCTTTCTCCTGGCAAGGGCTG
GGTTTTGCCGGCGCGGGGCTGGGATTAACCATTTCGCGCTACATCGGCGCGGTAGCGATTATTTGGGTGCTGATGATTGGTTTTAATCCG
GCGCTGCGCATTCCGCTGAAAAGCTATCTGAAGCCGCTGAATTTCGGCATTATCTGGGAAGTGATGGGTATCGGTATTCCGGCGAGCATT
GAATCAGTGCTGTTCAACGGTAGCAAGCTACTGACGCAAATGTTTGTCGCCGGAATGGGCACTAACGTTATTGCGGGTAACTTTATTGCC
TTTTCCGTGGCGGCGCTTATCAACCTGCCGGGTAACGCCCTTGGTTCGGCGTCGACTATTATCACCGGTAAGCGTCTTGGTACCGGGCAA
ATTGGTCAGGCAGAGCGTCAACTGCGCCATGTATTCTGGATGTCGACTATCGTACTTACGGCAATTGCCTGGGGGACGGCGCCGTTTGCG
GGTCTGTTTGCCTCATTTTATACCCAGGAGCAGGACGTAAAAGAGGTAGTGAAAGTTCTGCTCTGGCTTAATGCTGCCTTTATGCCAATT
TGGGCGGCCGCGTGGGTGTTGCCGTCGGGTTTTAAAGGCGCGCGCGATGTGCGATTTGCGATGTGGGTATCGATGCTGGGGATGTGGGGC
TGTCGCGTTGTGGCAGGGTATACGCTTGGTATTGTGCTGGGTATGGGGGTTGTAGGGGTTTGGCTGGGGATGTTTCTTGACTGGGCCGTG
CGTGGCGCACTGTTTTACTGGCGTCTGATAAGCGGGCGCTGGCTGTGGAGATACCCGCGCGTAAAGAGGGAGTAA