| Accession | ARO:3005049 |
| CARD Short Name | CrcB |
| Definition | CrcB is part of the Camphor Resistance Protein Family. It confers resistance to aminoglycoside antibiotics. |
| AMR Gene Family | multidrug and toxic compound extrusion (MATE) transporter |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Klebsiella pneumoniaeg+wgs |
| Resistomes with Sequence Variants | Klebsiella pneumoniaeg+wgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic efflux [Resistance Mechanism] + antibiotic mixture + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + aminoglycoside antibiotic [Drug Class] |
| Parent Term(s) | 4 ontology terms | Show + confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + multidrug and toxic compound extrusion (MATE) transporter [AMR Gene Family] + confers_resistance_to_antibiotic gentamicin [Antibiotic] |
| Publications | Fookes M, et al. 2013. Genome Announc 1(1): Genome Sequence of Klebsiella pneumoniae Ecl8, a Reference Strain for Targeted Genetic Manipulation. (PMID 23405357) Muraya A, et al. 2022. Pathogens 11(5): Antimicrobial Resistance and Virulence Characteristics of Klebsiella pneumoniae Isolates in Kenya by Whole-Genome Sequencing. (PMID 35631066) |
Prevalence of CrcB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Klebsiella pneumoniae | 4.62% | 0% | 4.24% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 250