| Accession | ARO:3004077 |
| Synonym(s) | PA1361 |
| CARD Short Name | PmpM |
| Definition | PmpM is a multidrug efflux pump belonging to the MATE family of Pseudomonas aeruginosa. PmpM is an H+ drug antiporter and is the first reported case of an H+ coupled efflux pump in the MATE family. PmpM confers resistance to fluoroquinolones, fradiomycin, benzalkonium chloride, chlorhexidine gluconate, ethidium bromide, tetraphenylphosphonium chloride (TPPCl), and rhodamine 6G. |
| AMR Gene Family | multidrug and toxic compound extrusion (MATE) transporter |
| Drug Class | disinfecting agents and antiseptics, aminoglycoside antibiotic, fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Pseudomonas aeruginosag+wgs, Pseudomonas fluorescensg |
| Resistomes with Sequence Variants | Pseudomonas aeruginosag+wgs, Pseudomonas fluorescensg |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic efflux [Resistance Mechanism] + disinfecting agents and antiseptics [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + aminoglycoside antibiotic [Drug Class] |
| Parent Term(s) | 5 ontology terms | Show + confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class] + confers_resistance_to_antibiotic neomycin [Antibiotic] + multidrug and toxic compound extrusion (MATE) transporter [AMR Gene Family] + confers_resistance_to_antibiotic benzalkonium chloride [Antibiotic] + confers_resistance_to_antibiotic chlorhexidine [Antibiotic] |
| Publications | He GX, et al. 2004. J. Bacteriol. 186(1):262-5 An H(+)-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa. (PMID 14679249) |
Prevalence of PmpM among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI | GRDI-AMR2 |
|---|---|---|---|---|---|
| Pseudomonas aeruginosa | 98.77% | 0% | 97.32% | 0% | 0% |
| Pseudomonas fluorescens | 2.78% | 0% | 0% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 900
| Curator | Description | Most Recent Edit |
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