nitrofurantoin [Antibiotic]

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Accession ARO:0000075
Synonym(s)Furadantine Macrodantina Furalan Chemiofuran Cistofuran Furadantin Macrobid Nitrofuradantin Macrodantin
DefinitionNitrofurantoin is an antibiotic used to treat urinary tract infections. It inhibits enzyme synthesis by inhibiting essential enzymes involved in the citric acid cycle, as well as those involved in DNA, RNA, and protein synthesis. It is marketed under the following brand names: Furadantin, Macrobid, Macrodantin, Nitro Macro and Urantoin.
Drug Classnitrofuran antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ nitrofuran antibiotic [Drug Class]
4 ontology terms | Show
+ deoxyribonucleic acid targeted_by_antibiotic
+ Escherichia coli nfsA mutations conferring resistance to nitrofurantoin confers_resistance_to_antibiotic
+ Escherichia coli nfsB with mutation conferring resistance to nitrofurantoin confers_resistance_to_antibiotic
+ oqxAB confers_resistance_to_antibiotic

McOsker CC and Fitzpatrick PM. 1994. J Antimicrob Chemother 33(SUPPL A): 23-30. Nitrofurantoin: mechanism of action and implications for resistance development in common uropathogens. (PMID 7928834)

Tu Y and McCalla DR. 1975. Biochim Biophys Acta 402(2): 142-149. Effect of activated nitrofurans on DNA. (PMID 1100114)