| Accession | ARO:3000336 |
| Definition | Point mutations in bacterial 23S rRNA from the large ribosomal subunit that confer resistance to antibiotics. Antibiotics such as linezolid block peptide synthesis through peptidyl transferase activity. Mutations in the 23S rRNA subunit reduce antibiotic binding affinity at specific sites, conferring resistance. |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 6 ontology terms | Show |
| Parent Term(s) | 2 ontology terms | Show |
| Sub-Term(s) | 8 ontology terms | Show + 23S rRNA with mutation conferring resistance to linezolid antibiotics [AMR Gene Family] + 23S rRNA with mutation conferring resistance to macrolide antibiotics [AMR Gene Family] + 23S rRNA with mutation conferring resistance to pleuromutilin antibiotics [AMR Gene Family] + 23S rRNA with mutation conferring resistance to streptogramins antibiotics [AMR Gene Family] + 23S rRNA with mutation conferring resistance to lincosamide antibiotics [AMR Gene Family] + 23S rRNA with mutation conferring resistance to phenicol antibiotics [AMR Gene Family] + 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics [AMR Gene Family] + 23s rRNA with mutation conferring resistance to aminoglycoside antibiotics [AMR Gene Family] |
| Publications | Arias CA, et al. 2008. J Clin Microbiol 46(3): 892-896. Clinical and microbiological aspects of linezolid resistance mediated by the cfr gene encoding a 23S rRNA methyltransferase. (PMID 18174304) Mukhtar TA and Wright GD. 2005. Chem Rev 105(2): 529-542. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (PMID 15700955) |