23S rRNA with mutation conferring antibiotic resistance

Accession ARO:3000336
DefinitionPoint mutations in bacterial 23S rRNA from the large ribosomal subunit that confer resistance to antibiotics. Antibiotics such as linezolid block peptide synthesis through peptidyl transferase activity. Mutations in the 23S rRNA subunit reduce antibiotic binding affinity at specific sites, conferring resistance.
Resistance Mechanismantibiotic target alteration
Classification6 ontology terms | Show
Parent Term(s)2 ontology terms | Show
8 ontology terms | Show

Arias CA, et al. 2008. J Clin Microbiol 46(3): 892-896. Clinical and microbiological aspects of linezolid resistance mediated by the cfr gene encoding a 23S rRNA methyltransferase. (PMID 18174304)

Mukhtar TA and Wright GD. 2005. Chem Rev 105(2): 529-542. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (PMID 15700955)