23S rRNA with mutation conferring resistance to pleuromutilin antibiotics [AMR Gene Family]

Accession ARO:3004178
DefinitionPoint mutations in the 23S rRNA subunit may confer resistance to pleuromutilin antibiotics.
Drug Classpleuromutilin antibiotic
Resistance Mechanismantibiotic target alteration
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
2 ontology terms | Show

Li BB, et al. 2010. FEMS Microbiol. Lett. 308(2):144-9 Mutations in 23S rRNA gene associated with decreased susceptibility to tiamulin and valnemulin in Mycoplasma gallisepticum. (PMID 20487023)

Long KS, et al. 2009. Mol. Microbiol. 71(5):1218-27 Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket. (PMID 19154331)