23S rRNA with mutation conferring resistance to pleuromutilin antibiotics [AMR Gene Family]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3004178
DefinitionPoint mutations in the 23S rRNA subunit may confer resistance to pleuromutilin antibiotics.
Drug Classglycopeptide antibiotic, streptogramin antibiotic, phenicol antibiotic, streptogramin B antibiotic, streptogramin A antibiotic, lincosamide antibiotic, macrolide antibiotic, pleuromutilin antibiotic
Resistance Mechanismantibiotic target alteration
Classification46 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ antibiotic mixture
+ glycopeptide antibiotic [Drug Class]
+ mechanism of antibiotic resistance
+ antibiotic target
+ antibiotic target alteration [Resistance Mechanism]
+ bleomycin [Antibiotic]
+ streptogramin antibiotic [Drug Class]
+ nucleic acid targeted by antibiotic
+ protein synthesis machinery targeted by antibiotic
+ bleomycin B2 [Antibiotic]
+ bleomycin A2 [Antibiotic]
+ bleomycinic acid [Antibiotic]
+ phenicol antibiotic [Drug Class]
+ mutation conferring antibiotic resistance
+ determinant of antibiotic resistance
+ streptogramin B antibiotic [Drug Class]
+ streptogramin A antibiotic [Drug Class]
+ lincosamide antibiotic [Drug Class]
+ macrolide antibiotic [Drug Class]
+ ribonucleic acid
+ 50S ribosomal subunit
+ ostreogrycin B3 [Antibiotic]
+ patricin B [Antibiotic]
+ patricin A [Antibiotic]
+ vernamycin C [Antibiotic]
+ pristinamycin IC [Antibiotic]
+ virginiamycin S2 [Antibiotic]
+ pristinamycin IB [Antibiotic]
+ dalfopristin [Antibiotic]
+ griseoviridin [Antibiotic]
+ madumycin II [Antibiotic]
+ pleuromutilin antibiotic [Drug Class]
+ virginiamycin M1 [Antibiotic]
+ quinupristin [Antibiotic]
+ pristinamycin IA [Antibiotic]
+ florfenicol [Antibiotic]
+ thiamphenicol [Antibiotic]
+ chloramphenicol [Antibiotic]
+ azidamfenicol [Antibiotic]
+ clindamycin [Antibiotic]
+ lincomycin [Antibiotic]
+ antibiotic resistant gene variant or mutant
+ antibiotic sensitive peptidyl transferase (23S rRNA)
+ rRNA with mutation conferring antibiotic resistance
Parent Term(s)2 ontology terms | Show
Sub-Term(s)
2 ontology terms | Show
Publications

Li BB, et al. 2010. FEMS Microbiol. Lett. 308(2):144-9 Mutations in 23S rRNA gene associated with decreased susceptibility to tiamulin and valnemulin in Mycoplasma gallisepticum. (PMID 20487023)

Long KS, et al. 2009. Mol. Microbiol. 71(5):1218-27 Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket. (PMID 19154331)
Curator Acknowledgements
Curator Description Most Recent Edit