| Accession | ARO:3000754 |
| Definition | The bacterial 23S rRNA, at the P site of the 50S subunit, has peptidyl transferase activity and is responsible for peptide synthesis and elongation. |
| Drug Class | lincosamide antibiotic, streptogramin antibiotic, streptogramin A antibiotic, phenicol antibiotic, pleuromutilin antibiotic |
| Classification | 4 ontology terms | Show |
| Parent Term(s) | 26 ontology terms | Show + targeted_by lincosamide antibiotic [Drug Class] + targeted_by streptogramin antibiotic [Drug Class] + targeted_by streptogramin A antibiotic [Drug Class] + targeted_by_antibiotic lincomycin [Antibiotic] + targeted_by_antibiotic clindamycin [Antibiotic] + targeted_by_antibiotic azidamfenicol [Antibiotic] + targeted_by_antibiotic chloramphenicol [Antibiotic] + targeted_by phenicol antibiotic [Drug Class] + targeted_by_antibiotic thiamphenicol [Antibiotic] + targeted_by_antibiotic florfenicol [Antibiotic] + targeted_by_antibiotic pristinamycin IA [Antibiotic] + targeted_by_antibiotic quinupristin [Antibiotic] + targeted_by_antibiotic virginiamycin M1 [Antibiotic] + targeted_by pleuromutilin antibiotic [Drug Class] + targeted_by_antibiotic madumycin II [Antibiotic] + targeted_by_antibiotic griseoviridin [Antibiotic] + targeted_by_antibiotic dalfopristin [Antibiotic] + targeted_by_antibiotic pristinamycin IB [Antibiotic] + targeted_by_antibiotic virginiamycin S2 [Antibiotic] + targeted_by_antibiotic pristinamycin IC [Antibiotic] + targeted_by_antibiotic vernamycin C [Antibiotic] + targeted_by_antibiotic patricin A [Antibiotic] + targeted_by_antibiotic patricin B [Antibiotic] + targeted_by_antibiotic ostreogrycin B3 [Antibiotic] + part_of 50S ribosomal subunit + ribonucleic acid |
| Sub-Term(s) | 1 ontology terms | Show + 23S rRNA with mutation conferring antibiotic resistance derives_from |
| Publications | Kirillov SV, et al. 1999. RNA 5(8): 1003-1013. Peptidyl transferase antibiotics perturb the relative positioning of the 3'-terminal adenosine of P/P'-site-bound tRNA and 23S rRNA in the ribosome. (PMID 10445875) Long KS, et al. 2006. Antimicrob Agents Chemother 50(4): 1458-1462. Interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center. (PMID 16569865) Polacek N and Mankin AS. 2005. Crit Rev Biochem Mol Biol 40(5): 285-311. The ribosomal peptidyl transferase center: structure, function, evolution, inhibition. (PMID 16257828) |