antibiotic sensitive peptidyl transferase (23S rRNA)

Accession ARO:3000754
DefinitionThe bacterial 23S rRNA, at the P site of the 50S subunit, has peptidyl transferase activity and is responsible for peptide synthesis and elongation.
Drug Classphenicol antibiotic, streptogramin antibiotic, pleuromutilin antibiotic, lincosamide antibiotic, streptogramin A antibiotic
Classification4 ontology terms | Show
Parent Term(s)26 ontology terms | Show
+ part_of 50S ribosomal subunit
+ targeted_by phenicol antibiotic [Drug Class]
+ targeted_by streptogramin antibiotic [Drug Class]
+ targeted_by pleuromutilin antibiotic [Drug Class]
+ targeted_by lincosamide antibiotic [Drug Class]
+ ribonucleic acid
+ targeted_by_antibiotic chloramphenicol [Antibiotic]
+ targeted_by_antibiotic florfenicol [Antibiotic]
+ targeted_by_antibiotic thiamphenicol [Antibiotic]
+ targeted_by_antibiotic azidamfenicol [Antibiotic]
+ targeted_by_antibiotic dalfopristin [Antibiotic]
+ targeted_by_antibiotic griseoviridin [Antibiotic]
+ targeted_by_antibiotic madumycin II [Antibiotic]
+ targeted_by_antibiotic virginiamycin M1 [Antibiotic]
+ targeted_by_antibiotic ostreogrycin B3 [Antibiotic]
+ targeted_by_antibiotic patricin A [Antibiotic]
+ targeted_by_antibiotic patricin B [Antibiotic]
+ targeted_by_antibiotic pristinamycin IA [Antibiotic]
+ targeted_by_antibiotic pristinamycin IB [Antibiotic]
+ targeted_by_antibiotic quinupristin [Antibiotic]
+ targeted_by_antibiotic pristinamycin IC [Antibiotic]
+ targeted_by_antibiotic vernamycin C [Antibiotic]
+ targeted_by_antibiotic virginiamycin S2 [Antibiotic]
+ targeted_by_antibiotic clindamycin [Antibiotic]
+ targeted_by_antibiotic lincomycin [Antibiotic]
+ targeted_by streptogramin A antibiotic [Drug Class]
1 ontology terms | Show

Kirillov SV, et al. 1999. RNA 5(8): 1003-1013. Peptidyl transferase antibiotics perturb the relative positioning of the 3'-terminal adenosine of P/P'-site-bound tRNA and 23S rRNA in the ribosome. (PMID 10445875)

Long KS, et al. 2006. Antimicrob Agents Chemother 50(4): 1458-1462. Interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center. (PMID 16569865)

Polacek N and Mankin AS. 2005. Crit Rev Biochem Mol Biol 40(5): 285-311. The ribosomal peptidyl transferase center: structure, function, evolution, inhibition. (PMID 16257828)