lincosamide antibiotic [Drug Class]

Accession ARO:0000017
Synonym(s)lincosamide
DefinitionLincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
23 ontology terms | Show
+ lincomycin [Antibiotic]
+ clindamycin [Antibiotic]
+ celesticetin [Antibiotic]
+ determinant of lincosamide resistance confers_resistance_to_drug_class
+ lmrP confers_resistance_to_drug_class
+ lmrC confers_resistance_to_drug_class
+ lmrD confers_resistance_to_drug_class
+ AdeIJK confers_resistance_to_drug_class
+ lmrAB Operon confers_resistance_to_drug_class
+ lsaB confers_resistance_to_drug_class
+ lsaC confers_resistance_to_drug_class
+ lsaE confers_resistance_to_drug_class
+ salA confers_resistance_to_drug_class
+ eatAv confers_resistance_to_drug_class
+ 23S rRNA with mutation conferring resistance to lincosamide antibiotics [AMR Gene Family] confers_resistance_to_drug_class
+ Llm 23S ribosomal RNA methyltransferase [AMR Gene Family] confers_resistance_to_drug_class
+ Erm 23S ribosomal RNA methyltransferase [AMR Gene Family] confers_resistance_to_drug_class
+ non-erm 23S ribosomal RNA methyltransferase (G748) [AMR Gene Family] confers_resistance_to_drug_class
+ lincosamide nucleotidyltransferase (LNU) [AMR Gene Family] confers_resistance_to_drug_class
+ ABC-F ATP-binding cassette ribosomal protection protein [AMR Gene Family] confers_resistance_to_drug_class
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] confers_resistance_to_drug_class
+ 23S rRNA with mutation conferring resistance to linezolid antibiotics [AMR Gene Family] confers_resistance_to_drug_class
+ antibiotic sensitive peptidyl transferase (23S rRNA) targeted_by
Publications

Roberts MC, et al. 1999. Antimicrob Agents Chemother 43(12): 2823-2830. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. (PMID 10582867)

Doktor SZ, et al. 2004. Diagn Microbiol Infect Dis 49(1): 47-52. Epidemiology of macrolide and/or lincosamide resistant Streptococcus pneumoniae clinical isolates with ribosomal mutations. (PMID 15135500)