| Accession | ARO:3003969 |
| CARD Short Name | lmrP |
| Definition | lmrP is a proton motive force-dependent drug transporter that is part of the MFS efflux pump family. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | streptogramin antibiotic, tetracycline antibiotic, streptogramin A antibiotic, macrolide antibiotic, lincosamide antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Streptococcus pyogenesg+wgs |
| Resistomes with Sequence Variants | Streptococcus pyogenesg+wgs |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + streptogramin antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + tetracycline antibiotic [Drug Class] + streptogramin A antibiotic [Drug Class] + macrolide antibiotic [Drug Class] |
| Parent Term(s) | 15 ontology terms | Show + confers_resistance_to_drug_class macrolide antibiotic [Drug Class] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_drug_class lincosamide antibiotic [Drug Class] + confers_resistance_to_drug_class streptogramin antibiotic [Drug Class] + confers_resistance_to_antibiotic roxithromycin [Antibiotic] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic clarithromycin [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_drug_class tetracycline antibiotic [Drug Class] + confers_resistance_to_antibiotic minocycline [Antibiotic] + confers_resistance_to_antibiotic azithromycin [Antibiotic] + confers_resistance_to_antibiotic chlortetracycline [Antibiotic] + confers_resistance_to_antibiotic demeclocycline [Antibiotic] + confers_resistance_to_antibiotic oxytetracycline [Antibiotic] + confers_resistance_to_antibiotic dalfopristin [Antibiotic] |
| Publications | van Veen HW, et al. . Antonie Van Leeuwenhoek 76(1-4):347-52 Multidrug resistance in lactic acid bacteria: molecular mechanisms and clinical relevance. (PMID 10532389) Bolhuis H, et al. 1995. J. Biol. Chem. 270(44):26092-8 The Lactococcal lmrP gene encodes a proton motive force-dependent drug transporter. (PMID 7592810) Putman M, et al. 2001. Microbiology (Reading, Engl.) 147(Pt 10):2873-80 The lactococcal secondary multidrug transporter LmrP confers resistance to lincosamides, macrolides, streptogramins and tetracyclines. (PMID 11577166) |
Prevalence of lmrP among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Streptococcus pyogenes | 7.84% | 0% | 4.58% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 800