roxithromycin [Antibiotic]

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Accession ARO:0000027
DefinitionRoxithromycin is a semi-synthetic, 14-carbon ring macrolide antibiotic derived from erythromycin. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.
Drug Classmacrolide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ macrolide antibiotic [Drug Class]
31 ontology terms | Show
+ EreA confers_resistance_to_antibiotic
+ EreB confers_resistance_to_antibiotic
+ ErmC confers_resistance_to_antibiotic
+ ErmE confers_resistance_to_antibiotic
+ ErmA confers_resistance_to_antibiotic
+ ErmB confers_resistance_to_antibiotic
+ Erm(37) confers_resistance_to_antibiotic
+ ErmD confers_resistance_to_antibiotic
+ ErmF confers_resistance_to_antibiotic
+ ErmG confers_resistance_to_antibiotic
+ ErmN confers_resistance_to_antibiotic
+ ErmQ confers_resistance_to_antibiotic
+ ErmR confers_resistance_to_antibiotic
+ ErmT confers_resistance_to_antibiotic
+ ErmX confers_resistance_to_antibiotic
+ Erm(33) confers_resistance_to_antibiotic
+ Erm(34) confers_resistance_to_antibiotic
+ Erm(38) confers_resistance_to_antibiotic
+ Erm(39) confers_resistance_to_antibiotic
+ Erm(41) confers_resistance_to_antibiotic
+ Erm(35) confers_resistance_to_antibiotic
+ Erm(36) confers_resistance_to_antibiotic
+ mphA confers_resistance_to_antibiotic
+ mphB confers_resistance_to_antibiotic
+ mphC confers_resistance_to_antibiotic
+ Erm(50) confers_resistance_to_antibiotic
+ mphF confers_resistance_to_antibiotic
+ RanA confers_resistance_to_antibiotic
+ RanB confers_resistance_to_antibiotic
+ lmrP confers_resistance_to_antibiotic
+ 50S ribosomal subunit P-site targeted_by_antibiotic

Gibreel A, et al. 2005. Antimicrob Agents Chemother 49(7): 2753-2759. Macrolide resistance in Campylobacter jejuni and Campylobacter coli: molecular mechanism and stability of the resistance phenotype. (PMID 15980346)

Roberts MC, et al. 1999. Antimicrob Agents Chemother 43(12): 2823-2830. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. (PMID 10582867)