| Accession | ARO:3000363 |
| Synonym(s) | Ere(B) |
| CARD Short Name | EreB |
| Definition | EreB is an erythromycin esterase-like protein that hydrolyses the drug's lactone ring. |
| AMR Gene Family | macrolide esterase |
| Drug Class | macrolide antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniig, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Klebsiella pneumoniaep+wgs, Morganella morganiig+wgs, Proteus mirabiliswgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniig, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Klebsiella pneumoniaep+wgs, Morganella morganiig+wgs, Proteus mirabiliswgs |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic molecule + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + macrolide inactivation enzyme + macrolide antibiotic [Drug Class] + hydrolysis of macrolide macrocycle lactone ring |
| Parent Term(s) | 5 ontology terms | Show + macrolide esterase [AMR Gene Family] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic clarithromycin [Antibiotic] + confers_resistance_to_antibiotic roxithromycin [Antibiotic] + confers_resistance_to_antibiotic azithromycin [Antibiotic] |
| Publications | Nakamura A, et al. 2000. J. Antibiot. 53(5):516-24 Macrolide esterase-producing Escherichia coli clinically isolated in Japan. (PMID 10908116) |
Prevalence of EreB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0.18% | 0% | 0% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.04% | 0% |
| Enterobacter kobei | 0% | 0% | 1.31% | 0% |
| Escherichia coli | 0% | 0% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0.01% | 0.1% | 0% |
| Morganella morganii | 3.85% | 0% | 3.07% | 0% |
| Proteus mirabilis | 0% | 0% | 0.17% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700