macrolide esterase [AMR Gene Family]

Accession ARO:3000320
DefinitionHydrolytic enzymes that cleave the macrocycle lactone ring of macrolide antibiotics.
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic inactivation
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ macrolide inactivation enzyme
+ participates_in hydrolysis of macrolide macrocycle lactone ring
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
5 ontology terms | Show
+ EreA
+ EreB
+ EreA2
+ EreD
+ EstT

Morar M, et al. 2012. Biochemistry 51(8): 1740-1751. Mechanism and diversity of the erythromycin esterase family of enzymes. (PMID 22303981)