| Accession | ARO:3004608 |
| Synonym(s) | Ere(D) |
| CARD Short Name | EreD |
| Definition | EreD is an erythromycin esterase protein. |
| AMR Gene Family | macrolide esterase |
| Drug Class | macrolide antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Elizabethkingia anopheliswgs, Riemerella anatipestiferg+wgs |
| Resistomes with Sequence Variants | Bacteroides fragilisg+gi, Bacteroides ovatusp, Bacteroides thetaiotaomicrong+p+wgs, Chryseobacterium taklimakanenseg, Elizabethkingia anophelisg+wgs, Myroides odoratimimusg+wgs+gi, Myroides phaeusg+gi, Phocaeicola doreiwgs, Phocaeicola vulgatuswgs, Riemerella anatipestiferg+p+wgs |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + antibiotic molecule + hydrolysis of macrolide macrocycle lactone ring + macrolide inactivation enzyme + macrolide antibiotic [Drug Class] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Xing L, et al. 2015. PLoS One 10(6):e0131078 ErmF and ereD are responsible for erythromycin resistance in Riemerella anatipestifer. (PMID 26107936) |
Prevalence of EreD among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Bacteroides fragilis | 3.85% | 0% | 0% | 9.09% |
| Bacteroides ovatus | 0% | 2.94% | 0% | 0% |
| Bacteroides thetaiotaomicron | 3.57% | 2.27% | 1.75% | 0% |
| Chryseobacterium taklimakanense | 33.33% | 0% | 0% | 0% |
| Elizabethkingia anophelis | 7.69% | 0% | 3.09% | 0% |
| Myroides odoratimimus | 100% | 0% | 7.14% | 50% |
| Myroides phaeus | 100% | 0% | 0% | 50% |
| Phocaeicola dorei | 0% | 0% | 1.04% | 0% |
| Phocaeicola vulgatus | 0% | 0% | 0.84% | 0% |
| Riemerella anatipestifer | 13.89% | 15.38% | 11.81% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400