| Accession | ARO:3000361 |
| Synonym(s) | Ere(A) |
| CARD Short Name | EreA |
| Definition | EreA is an erythromycin esterase that hydrolyses the drug's lactone ring. |
| AMR Gene Family | macrolide esterase |
| Drug Class | macrolide antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Enterobacter hormaecheiwgs, Klebsiella pneumoniaewgs, Pseudomonas aeruginosawgs, Pseudomonas putidawgs |
| Resistomes with Sequence Variants | Actinobacillus pleuropneumoniaeg, Aliarcobacter butzleriwgs, Citrobacter freundiiwgs, Enterobacter cloacaewgs, Enterobacter hormaecheip+wgs, Escherichia colig+wgs, Klebsiella pneumoniaeg+wgs+gi, Klebsiella quasipneumoniaewgs, Laribacter hongkongensisg+wgs+gi, Proteus mirabilisg+wgs+gi, Pseudomonas aeruginosag+wgs, Pseudomonas putidag+wgs, Salmonella entericawgs, Serratia marcescensp, Vibrio alginolyticusg, Vibrio parahaemolyticuswgs |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + hydrolysis of macrolide macrocycle lactone ring + macrolide antibiotic [Drug Class] + macrolide inactivation enzyme |
| Parent Term(s) | 4 ontology terms | Show + macrolide esterase [AMR Gene Family] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic clarithromycin [Antibiotic] + confers_resistance_to_antibiotic roxithromycin [Antibiotic] |
| Publications | Morar M, et al. 2012. Biochemistry 51(8): 1740-1751. Mechanism and diversity of the erythromycin esterase family of enzymes. (PMID 22303981) |
Prevalence of EreA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Actinobacillus pleuropneumoniae | 2.78% | 0% | 0% | 0% |
| Aliarcobacter butzleri | 0% | 0% | 0.81% | 0% |
| Citrobacter freundii | 0% | 0% | 0.77% | 0% |
| Enterobacter cloacae | 0% | 0% | 0.32% | 0% |
| Enterobacter hormaechei | 0% | 0.06% | 0.13% | 0% |
| Escherichia coli | 0.05% | 0% | 0.03% | 0% |
| Klebsiella pneumoniae | 0.06% | 0% | 0.08% | 0.95% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.13% | 0% |
| Laribacter hongkongensis | 66.67% | 0% | 2.08% | 50% |
| Proteus mirabilis | 19.27% | 0% | 3.96% | 18.52% |
| Pseudomonas aeruginosa | 0.15% | 0% | 0.09% | 0% |
| Pseudomonas putida | 1.41% | 0% | 0.53% | 0% |
| Salmonella enterica | 0% | 0% | 0.02% | 0% |
| Serratia marcescens | 0% | 0.65% | 0% | 0% |
| Vibrio alginolyticus | 1.23% | 0% | 0% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.05% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 650