| Accession | ARO:3007459 |
| CARD Short Name | EstT |
| Definition | EstT is a gene encoding for a serine-dependent macrolide alpha/beta-hydrolase. |
| AMR Gene Family | macrolide esterase |
| Drug Class | tetracycline antibiotic, macrolide antibiotic, glycylcycline |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Glaesserella parasuiswgs, Riemerella anatipestiferg+wgs |
| Resistomes with Sequence Variants | Actinobacillus indolicuswgs, Bacteroides ovatuswgs, Bacteroides thetaiotaomicronwgs, Escherichia coliwgs, Glaesserella parasuiswgs, Histophilus somniwgs, Myroides odoratimimuswgs, Pasteurella multocidawgs, Phocaeicola vulgatuswgs, Riemerella anatipestiferg+p+wgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic molecule + tetracycline antibiotic [Drug Class] + hydrolysis of antibiotic conferring resistance + antibiotic inactivation enzyme + hydrolysis of macrolide macrocycle lactone ring + macrolide antibiotic [Drug Class] + macrolide inactivation enzyme + glycylcycline [Drug Class] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Dhindwal P, et al. 2023. Proc Natl Acad Sci U S A 120(8):e2219827120 A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase. (PMID 36791107) |
Prevalence of EstT among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Actinobacillus indolicus | 0% | 0% | 100% | 0% |
| Bacteroides ovatus | 0% | 0% | 0.38% | 0% |
| Bacteroides thetaiotaomicron | 0% | 0% | 1.4% | 0% |
| Escherichia coli | 0% | 0% | 0.02% | 0% |
| Glaesserella parasuis | 0% | 0% | 5.13% | 0% |
| Histophilus somni | 0% | 0% | 34.48% | 0% |
| Myroides odoratimimus | 0% | 0% | 7.14% | 0% |
| Pasteurella multocida | 0% | 0% | 0.37% | 0% |
| Phocaeicola vulgatus | 0% | 0% | 0.84% | 0% |
| Riemerella anatipestifer | 33.33% | 7.69% | 11.11% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 600