EreA2

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Accession ARO:3002826
Synonym(s)Ere(A2)
CARD Short NameEreA2
DefinitionEreA2 is an integron-encoded erythromycin esterase that hydrolyses the drug's lactone ring. EreA2 is found in Providencia stuartii.
AMR Gene Familymacrolide esterase
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAcinetobacter johnsoniiwgs, Aeromonas caviaewgs, Citrobacter freundiiwgs, Citrobacter werkmaniiwgs, Enterobacter asburiaep, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Escherichia colig+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Proteus vulgariswgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Pseudomonas putidawgs, Salmonella entericawgs, Shigella flexnerip
Resistomes with Sequence VariantsAcinetobacter johnsoniiwgs, Aeromonas caviaewgs, Citrobacter freundiiwgs, Citrobacter werkmaniiwgs, Enterobacter asburiaep, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiiwgs, Proteus vulgariswgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Pseudomonas putidawgs, Pseudomonas stutzeriwgs, Salmonella entericawgs+gi, Shigella flexnerip
Classification10 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ macrolide esterase [AMR Gene Family]
Publications

Plante I, et al. 2003. J Antimicrob Chemother 51(4): 787-790. An integron cassette encoding erythromycin esterase, ere(A), from Providencia stuartii. (PMID 12654734)
Resistomes

Prevalence of EreA2 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Acinetobacter johnsonii0%0%1.82%0%0%
Aeromonas caviae0%0%0.54%0%0%
Citrobacter freundii0%0%0.39%0%0%
Citrobacter werkmanii0%0%48.72%0%0%
Enterobacter asburiae0%0.28%0%0%0%
Enterobacter hormaechei0%0%1.21%0%0%
Enterobacter kobei0%0%0.44%0%0%
Enterobacter roggenkampii0%0%0.72%0%0%
Escherichia coli0.02%0.01%0.06%0%0%
Klebsiella oxytoca0%0%1.26%0%0%
Klebsiella pneumoniae0%0.26%0.98%0%0%
Klebsiella quasipneumoniae0%0%0.13%0%0%
Morganella morganii0%0%0.61%0%0%
Proteus vulgaris0%0%5.56%0%0%
Providencia rettgeri0%0%0.64%0%0%
Pseudomonas aeruginosa0%0%0.19%0%0%
Pseudomonas putida0%0%1.07%0%0%
Pseudomonas stutzeri0%0%0.76%0%0%
Salmonella enterica0%0%0.01%0.33%0%
Shigella flexneri0%0.4%0%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 700


>gb|AAC78336.1|+|EreA2 [Providencia stuartii]
MTWRTTRTLLQPQKLEFNEFEILNPVVEGARIVGIGEGAHFVAEFSLARASLIRYFVERHDFNAIGLECGAIQASRLSEWLNSTAGAHEL
ERFSDTLTFSLYGSVLIWVKSYLRESGRKLQLVGIDLPNTLNPRDDLAQLAEIIQVIDHLMKPHVDALTQLLTSIDGQSAVISSAKWGEL
ETAQQEKAISGVTRLKLRLASLAPVLKNHVNSDFFRKASDRIESIEYTLETLRVMKAFFDGTSLEGDTSVRDSYMAGVVDGMVRANPDVR
IILLAHNNHLQKTPVSFSGELTAVPMGQHLAEREEGDYRAIAFTHLGLTVPEMHFPSPDSPLGFSVVTTPADAIREDSVEQYVIDACGKE
DSCLTLTDDPMEAKRMRSQSASVETNLSEAFDAIVCVPSAGKDSLVAL


>gb|AF099140.1|+|137-1363|EreA2 [Providencia stuartii]
ATGACATGGAGAACGACCAGAACACTTTTACAGCCTCAAAAGCTGGAGTTCAATGAGTTTGAGATTCTTAATCCCGTAGTTGAGGGCGCC
CGAATTGTCGGCATTGGCGAGGGTGCTCACTTTGTCGCGGAGTTCTCACTGGCTAGAGCTAGTCTTATTCGCTATTTTGTCGAGAGGCAT
GATTTTAATGCGATTGGTTTGGAATGTGGGGCGATTCAGGCATCCCGGCTATCTGAATGGCTCAACTCAACAGCCGGTGCTCATGAACTT
GAGCGATTTTCGGATACCCTGACCTTTTCTTTGTATGGCTCAGTGCTGATTTGGGTTAAATCATATCTACGCGAATCAGGAAGAAAACTG
CAGTTAGTCGGAATCGATTTACCCAACACCTTGAATCCAAGGGACGACCTAGCGCAATTGGCCGAAATTATCCAGGTCATCGACCACCTC
ATGAAACCCCACGTTGATGCGCTGACTCAGTTGTTGACGTCCATTGATGGCCAGTCGGCGGTTATTTCATCGGCAAAATGGGGGGAGTTG
GAAACGGCTCAGCAGGAGAAAGCTATCTCAGGGGTAACCAGATTGAAGCTCCGTTTGGCGTCGCTTGCCCCTGTCCTGAAAAATCACGTC
AACAGCGATTTTTTCCGAAAAGCCTCTGATCGAATAGAGTCGATAGAGTATACGTTGGAAACCTTGCGTGTAATGAAAGCTTTCTTCGAT
GGTACCTCTCTTGAGGGAGATACTTCCGTACGTGACTCGTATATGGCGGGCGTGGTGGATGGAATGGTTCGAGCGAATCCGGATGTAAGG
ATAATTCTGCTGGCGCACAACAATCATTTACAAAAAACTCCAGTTTCCTTTTCAGGCGAGCTTACGGCTGTTCCCATGGGACAGCATCTC
GCAGAGAGGGAGGAGGGGGATTACCGTGCGATTGCATTCACCCATCTTGGACTCACCGTGCCGGAAATGCATTTCCCATCGCCCGACAGT
CCTCTTGGATTCTCTGTTGTGACCACGCCTGCCGATGCAATCCGTGAGGATAGTGTGGAACAGTATGTCATCGATGCCTGTGGTAAGGAG
GATTCATGCCTGACATTGACAGATGACCCCATGGAAGCAAAGCGAATGCGGTCCCAAAGCGCCTCTGTAGAAACGAATTTGAGCGAGGCA
TTTGATGCCATCGTCTGCGTTCCCAGCGCCGGCAAGGACAGCCTGGTTGCCCTATAG

Curator Acknowledgements
Curator Description Most Recent Edit