| Accession | ARO:3000375 |
| Synonym(s) | ermBC erm ermBP ermBZ1 ermAM ermP ermBZ2 ermIP ermAMR erm2 |
| CARD Short Name | ErmB |
| Definition | ErmB confers the MLSb phenotype. Similar to ErmC, expression of ErmB is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmB. |
| AMR Gene Family | Erm 23S ribosomal RNA methyltransferase |
| Drug Class | streptogramin antibiotic, macrolide antibiotic, streptogramin A antibiotic, streptogramin B antibiotic, lincosamide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+p, Acinetobacter townerip, Aliarcobacter butzlerig+p, Anaerostipes hadrusg, Bacillus subtilisg, Bacillus thuringiensisp, Bacteroides fragilisg, Bacteroides ovatusg, Butyricimonas faecalisg, Campylobacter colig, Campylobacter jejunig, Citrobacter amalonaticusp, Clostridium perfringensp, Eggerthella lentag, Enterococcus aviump, Enterococcus faecalisg+p, Enterococcus faeciumg+p, Enterococcus hiraeg+p, Escherichia colig+p, Eubacterium maltosivoransg, Faecalibacterium prausnitziig, Fusobacterium nucleatumg, Gemella morbillorumg, Jeotgalibaca arthritidisg, Klebsiella oxytocap, Klebsiella pneumoniaep, Lactobacillus crispatusg, Lactobacillus inersg, Lactobacillus johnsoniig, Lactococcus garvieaep, Listeria innocuap, Phocaeicola doreig, Salmonella entericag+p, Shigella flexnerip, Shigella sonneip, Staphylococcus aureusg+p, Staphylococcus pseudintermediusg, Streptococcus agalactiaeg, Streptococcus anginosusg, Streptococcus cristatusg, Streptococcus dysgalactiaeg, Streptococcus gallolyticusg, Streptococcus gordoniig, Streptococcus gwangjuenseg, Streptococcus iniaep, Streptococcus intermediusg, Streptococcus lutetiensisg, Streptococcus mutansp, Streptococcus pasteurianusg, Streptococcus pneumoniaeg, Streptococcus pseudopneumoniaeg, Streptococcus pyogenesg, Streptococcus suisg+p |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + antibiotic molecule + ribosomal alteration conferring antibiotic resistance + antibiotic target modifying enzyme + streptogramin antibiotic [Drug Class] + rRNA methyltransferase conferring antibiotic resistance + macrolide antibiotic [Drug Class] + streptogramin A antibiotic [Drug Class] + streptogramin B antibiotic [Drug Class] + 23S ribosomal RNA methyltransferase + lincosamide antibiotic [Drug Class] |
| Parent Term(s) | 25 ontology terms | Show + Erm 23S ribosomal RNA methyltransferase [AMR Gene Family] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic roxithromycin [Antibiotic] + confers_resistance_to_antibiotic telithromycin [Antibiotic] + confers_resistance_to_antibiotic clarithromycin [Antibiotic] + confers_resistance_to_antibiotic tylosin [Antibiotic] + confers_resistance_to_antibiotic spiramycin [Antibiotic] + confers_resistance_to_antibiotic azithromycin [Antibiotic] + confers_resistance_to_antibiotic dirithromycin [Antibiotic] + confers_resistance_to_antibiotic dalfopristin [Antibiotic] + confers_resistance_to_antibiotic griseoviridin [Antibiotic] + confers_resistance_to_antibiotic madumycin II [Antibiotic] + confers_resistance_to_antibiotic virginiamycin M1 [Antibiotic] + confers_resistance_to_antibiotic ostreogrycin B3 [Antibiotic] + confers_resistance_to_antibiotic patricin A [Antibiotic] + confers_resistance_to_antibiotic patricin B [Antibiotic] + confers_resistance_to_antibiotic pristinamycin IA [Antibiotic] + confers_resistance_to_antibiotic pristinamycin IB [Antibiotic] + confers_resistance_to_antibiotic quinupristin [Antibiotic] + confers_resistance_to_antibiotic pristinamycin IC [Antibiotic] + confers_resistance_to_antibiotic vernamycin C [Antibiotic] + confers_resistance_to_antibiotic virginiamycin S2 [Antibiotic] + confers_resistance_to_antibiotic lincomycin [Antibiotic] + confers_resistance_to_antibiotic clindamycin [Antibiotic] + confers_resistance_to_antibiotic oleandomycin [Antibiotic] |
| Publications | Min YH, et al. 2008. Antimicrob Agents Chemother 52(5): 1782-1789. Translational attenuation and mRNA stabilization as mechanisms of erm(B) induction by erythromycin. (PMID 18299414) Yu L, et al. 1997. Nat Struct Biol 4(6): 483-489. Solution structure of an rRNA methyltransferase (ErmAM) that confers macrolide-lincosamide-streptogramin antibiotic resistance. (PMID 9187657) Hajduk PJ, et al. 1999. J Med Chem 42(19): 3852-3859. Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis. (PMID 10508434) |
Prevalence of ErmB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 381 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0.18% | 0.05% | 0% | 0% |
| Acinetobacter towneri | 0% | 18.75% | 0% | 0% |
| Aliarcobacter butzleri | 12.5% | 33.33% | 0% | 0% |
| Anaerostipes hadrus | 66.67% | 0% | 0% | 0% |
| Bacillus subtilis | 1.43% | 0% | 0% | 0% |
| Bacillus thuringiensis | 0% | 0.07% | 0% | 0% |
| Bacteroides fragilis | 3.85% | 0% | 0% | 0% |
| Bacteroides ovatus | 6.67% | 0% | 0% | 0% |
| Butyricimonas faecalis | 100% | 0% | 0% | 0% |
| Campylobacter coli | 17.39% | 0% | 0% | 0% |
| Campylobacter jejuni | 0.7% | 0% | 0% | 0% |
| Citrobacter amalonaticus | 0% | 8.33% | 0% | 0% |
| Clostridium perfringens | 0% | 0.97% | 0% | 0% |
| Eggerthella lenta | 10% | 0% | 0% | 0% |
| Enterococcus avium | 0% | 33.33% | 0% | 0% |
| Enterococcus faecalis | 15.91% | 25.62% | 0% | 0% |
| Enterococcus faecium | 3.82% | 15.93% | 0% | 0% |
| Enterococcus hirae | 7.69% | 19.05% | 0% | 0% |
| Escherichia coli | 0.36% | 0.8% | 0% | 0% |
| Eubacterium maltosivorans | 100% | 0% | 0% | 0% |
| Faecalibacterium prausnitzii | 33.33% | 0% | 0% | 0% |
| Fusobacterium nucleatum | 8.33% | 0% | 0% | 0% |
| Gemella morbillorum | 33.33% | 0% | 0% | 0% |
| Jeotgalibaca arthritidis | 100% | 0% | 0% | 0% |
| Klebsiella oxytoca | 0% | 0.68% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0.49% | 0% | 0% |
| Lactobacillus crispatus | 8% | 0% | 0% | 0% |
| Lactobacillus iners | 28.57% | 0% | 0% | 0% |
| Lactobacillus johnsonii | 16.67% | 0% | 0% | 0% |
| Lactococcus garvieae | 0% | 8.33% | 0% | 0% |
| Listeria innocua | 0% | 10.53% | 0% | 0% |
| Phocaeicola dorei | 9.09% | 0% | 0% | 0% |
| Salmonella enterica | 0.06% | 0.27% | 0% | 0% |
| Shigella flexneri | 0% | 4.42% | 0% | 0% |
| Shigella sonnei | 0% | 2.91% | 0% | 0% |
| Staphylococcus aureus | 3.14% | 0.56% | 0% | 0% |
| Staphylococcus pseudintermedius | 46.67% | 0% | 0% | 0% |
| Streptococcus agalactiae | 17.76% | 0% | 0% | 0% |
| Streptococcus anginosus | 5.88% | 0% | 0% | 0% |
| Streptococcus cristatus | 50% | 0% | 0% | 0% |
| Streptococcus dysgalactiae | 2% | 0% | 0% | 0% |
| Streptococcus gallolyticus | 10% | 0% | 0% | 0% |
| Streptococcus gordonii | 7.14% | 0% | 0% | 0% |
| Streptococcus gwangjuense | 100% | 0% | 0% | 0% |
| Streptococcus iniae | 0% | 100% | 0% | 0% |
| Streptococcus intermedius | 14.29% | 0% | 0% | 0% |
| Streptococcus lutetiensis | 14.29% | 0% | 0% | 0% |
| Streptococcus mutans | 0% | 33.33% | 0% | 0% |
| Streptococcus pasteurianus | 75% | 0% | 0% | 0% |
| Streptococcus pneumoniae | 21.84% | 0% | 0% | 0% |
| Streptococcus pseudopneumoniae | 100% | 0% | 0% | 0% |
| Streptococcus pyogenes | 5.22% | 0% | 0% | 0% |
| Streptococcus suis | 58.4% | 12.9% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400
