Accession ARO:3000375
Synonym(s)ermBC erm ermBP ermBZ1 ermAM ermP ermBZ2 ermIP ermAMR erm2
CARD Short NameErmB
DefinitionErmB confers the MLSb phenotype. Similar to ErmC, expression of ErmB is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmB.
AMR Gene FamilyErm 23S ribosomal RNA methyltransferase
Drug Classstreptogramin antibiotic, macrolide antibiotic, streptogramin A antibiotic, streptogramin B antibiotic, lincosamide antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Sequence VariantsAcinetobacter baumanniig+p, Acinetobacter townerip, Aliarcobacter butzlerig+p, Anaerostipes hadrusg, Bacillus subtilisg, Bacillus thuringiensisp, Bacteroides fragilisg, Bacteroides ovatusg, Butyricimonas faecalisg, Campylobacter colig, Campylobacter jejunig, Citrobacter amalonaticusp, Clostridium perfringensp, Eggerthella lentag, Enterococcus aviump, Enterococcus faecalisg+p, Enterococcus faeciumg+p, Enterococcus hiraeg+p, Escherichia colig+p, Eubacterium maltosivoransg, Faecalibacterium prausnitziig, Fusobacterium nucleatumg, Gemella morbillorumg, Jeotgalibaca arthritidisg, Klebsiella oxytocap, Klebsiella pneumoniaep, Lactobacillus crispatusg, Lactobacillus inersg, Lactobacillus johnsoniig, Lactococcus garvieaep, Listeria innocuap, Phocaeicola doreig, Salmonella entericag+p, Shigella flexnerip, Shigella sonneip, Staphylococcus aureusg+p, Staphylococcus pseudintermediusg, Streptococcus agalactiaeg, Streptococcus anginosusg, Streptococcus cristatusg, Streptococcus dysgalactiaeg, Streptococcus gallolyticusg, Streptococcus gordoniig, Streptococcus gwangjuenseg, Streptococcus iniaep, Streptococcus intermediusg, Streptococcus lutetiensisg, Streptococcus mutansp, Streptococcus pasteurianusg, Streptococcus pneumoniaeg, Streptococcus pseudopneumoniaeg, Streptococcus pyogenesg, Streptococcus suisg+p
Classification14 ontology terms | Show
Parent Term(s)25 ontology terms | Show
+ Erm 23S ribosomal RNA methyltransferase [AMR Gene Family]
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic roxithromycin [Antibiotic]
+ confers_resistance_to_antibiotic telithromycin [Antibiotic]
+ confers_resistance_to_antibiotic clarithromycin [Antibiotic]
+ confers_resistance_to_antibiotic tylosin [Antibiotic]
+ confers_resistance_to_antibiotic spiramycin [Antibiotic]
+ confers_resistance_to_antibiotic azithromycin [Antibiotic]
+ confers_resistance_to_antibiotic dirithromycin [Antibiotic]
+ confers_resistance_to_antibiotic dalfopristin [Antibiotic]
+ confers_resistance_to_antibiotic griseoviridin [Antibiotic]
+ confers_resistance_to_antibiotic madumycin II [Antibiotic]
+ confers_resistance_to_antibiotic virginiamycin M1 [Antibiotic]
+ confers_resistance_to_antibiotic ostreogrycin B3 [Antibiotic]
+ confers_resistance_to_antibiotic patricin A [Antibiotic]
+ confers_resistance_to_antibiotic patricin B [Antibiotic]
+ confers_resistance_to_antibiotic pristinamycin IA [Antibiotic]
+ confers_resistance_to_antibiotic pristinamycin IB [Antibiotic]
+ confers_resistance_to_antibiotic quinupristin [Antibiotic]
+ confers_resistance_to_antibiotic pristinamycin IC [Antibiotic]
+ confers_resistance_to_antibiotic vernamycin C [Antibiotic]
+ confers_resistance_to_antibiotic virginiamycin S2 [Antibiotic]
+ confers_resistance_to_antibiotic lincomycin [Antibiotic]
+ confers_resistance_to_antibiotic clindamycin [Antibiotic]
+ confers_resistance_to_antibiotic oleandomycin [Antibiotic]
Publications

Min YH, et al. 2008. Antimicrob Agents Chemother 52(5): 1782-1789. Translational attenuation and mRNA stabilization as mechanisms of erm(B) induction by erythromycin. (PMID 18299414)

Yu L, et al. 1997. Nat Struct Biol 4(6): 483-489. Solution structure of an rRNA methyltransferase (ErmAM) that confers macrolide-lincosamide-streptogramin antibiotic resistance. (PMID 9187657)

Hajduk PJ, et al. 1999. J Med Chem 42(19): 3852-3859. Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis. (PMID 10508434)

Resistomes

Prevalence of ErmB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 381 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii0.18%0.05%0%0%
Acinetobacter towneri0%18.75%0%0%
Aliarcobacter butzleri12.5%33.33%0%0%
Anaerostipes hadrus66.67%0%0%0%
Bacillus subtilis1.43%0%0%0%
Bacillus thuringiensis0%0.07%0%0%
Bacteroides fragilis3.85%0%0%0%
Bacteroides ovatus6.67%0%0%0%
Butyricimonas faecalis100%0%0%0%
Campylobacter coli17.39%0%0%0%
Campylobacter jejuni0.7%0%0%0%
Citrobacter amalonaticus0%8.33%0%0%
Clostridium perfringens0%0.97%0%0%
Eggerthella lenta10%0%0%0%
Enterococcus avium0%33.33%0%0%
Enterococcus faecalis15.91%25.62%0%0%
Enterococcus faecium3.82%15.93%0%0%
Enterococcus hirae7.69%19.05%0%0%
Escherichia coli0.36%0.8%0%0%
Eubacterium maltosivorans100%0%0%0%
Faecalibacterium prausnitzii33.33%0%0%0%
Fusobacterium nucleatum8.33%0%0%0%
Gemella morbillorum33.33%0%0%0%
Jeotgalibaca arthritidis100%0%0%0%
Klebsiella oxytoca0%0.68%0%0%
Klebsiella pneumoniae0%0.49%0%0%
Lactobacillus crispatus8%0%0%0%
Lactobacillus iners28.57%0%0%0%
Lactobacillus johnsonii16.67%0%0%0%
Lactococcus garvieae0%8.33%0%0%
Listeria innocua0%10.53%0%0%
Phocaeicola dorei9.09%0%0%0%
Salmonella enterica0.06%0.27%0%0%
Shigella flexneri0%4.42%0%0%
Shigella sonnei0%2.91%0%0%
Staphylococcus aureus3.14%0.56%0%0%
Staphylococcus pseudintermedius46.67%0%0%0%
Streptococcus agalactiae17.76%0%0%0%
Streptococcus anginosus5.88%0%0%0%
Streptococcus cristatus50%0%0%0%
Streptococcus dysgalactiae2%0%0%0%
Streptococcus gallolyticus10%0%0%0%
Streptococcus gordonii7.14%0%0%0%
Streptococcus gwangjuense100%0%0%0%
Streptococcus iniae0%100%0%0%
Streptococcus intermedius14.29%0%0%0%
Streptococcus lutetiensis14.29%0%0%0%
Streptococcus mutans0%33.33%0%0%
Streptococcus pasteurianus75%0%0%0%
Streptococcus pneumoniae21.84%0%0%0%
Streptococcus pseudopneumoniae100%0%0%0%
Streptococcus pyogenes5.22%0%0%0%
Streptococcus suis58.4%12.9%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|AAF86219.1|+|ErmB [Enterococcus faecium]
MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTTKLAKISKQVTSIELDSHLFNLSSEKLKLNTRVTLIHQDILQFQFP
NKQRYKIVGSIPYNLSTQIIKKVVFESRASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAECFHPKPKVNSVLIKLTRHTT
DVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHAKVNNLSTITYEQVLSIFNSYLLFNGRKLIL


>gb|AF242872.1|+|2132-2878|ErmB [Enterococcus faecium]
ATGAACAAAAATATAAAATATTCTCAAAACTTTTTAACGAGTGAAAAAGTACTCAACCAAATAATAAAACAATTGAATTTAAAAGAAACC
GATACCGTTTACGAAATTGGAACAGGTAAAGGGCATTTAACGACGAAACTGGCTAAAATAAGTAAACAGGTAACGTCTATTGAATTAGAC
AGTCATCTATTCAACTTATCGTCAGAAAAATTAAAACTGAATACTCGTGTCACTTTAATTCACCAAGATATTCTACAGTTTCAATTCCCT
AACAAACAGAGGTATAAAATTGTTGGGAGTATTCCTTACAATTTAAGCACACAAATTATTAAAAAAGTGGTTTTTGAAAGCCGTGCGTCT
GACATCTATCTGATTGTTGAAGAAGGATTCTACAAGCGTACCTTGGATATTCACCGAACACTAGGGTTGCTCTTGCACACTCAAGTCTCG
ATTCAGCAATTGCTTAAGCTGCCAGCGGAATGCTTTCATCCTAAACCAAAAGTAAACAGTGTCTTAATAAAACTTACCCGCCATACCACA
GATGTTCCAGATAAATATTGGAAGCTATATACGTACTTTGTTTCAAAATGGGTCAATCGAGAATATCGTCAACTGTTTACTAAAAATCAG
TTTCATCAAGCAATGAAACACGCCAAAGTAAACAATTTAAGTACCATTACTTATGAGCAAGTATTGTCTATTTTTAATAGTTATCTATTA
TTTAACGGGAGGAAATTAATTCTATGA