| Accession | ARO:3000375 |
| Synonym(s) | ermBC erm ermBP ermBZ1 ermAM ermP ermBZ2 ermIP ermAMR erm2 |
| CARD Short Name | ErmB |
| Definition | ErmB confers the MLSb phenotype. Similar to ErmC, expression of ErmB is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmB. |
| AMR Gene Family | Erm 23S ribosomal RNA methyltransferase |
| Drug Class | streptogramin antibiotic, macrolide antibiotic, lincosamide antibiotic, streptogramin A antibiotic, streptogramin B antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Perfect Matches | Enterococcus faeciumwgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+p+wgs, Acinetobacter townerip, Aliarcobacter butzlerig+p, Anaerostipes hadrusg+wgs+gi, Bacillus subtilisg+wgs, Bacillus thuringiensisp+wgs, Bacteroides caccaewgs, Bacteroides fragilisg+wgs+gi, Bacteroides ovatusg+wgs, Bacteroides thetaiotaomicronwgs, Bifidobacterium brevewgs, Butyricimonas faecalisg+gi, Campylobacter colig+wgs+gi, Campylobacter jejunig+wgs, Citrobacter amalonaticusp, Citrobacter freundiiwgs, Citrobacter portucalensiswgs, Clostridioides difficilegi, Clostridium butyricumwgs, Clostridium perfringensp+wgs, Clostridium sporogenesgi, Collinsella aerofacienswgs, Eggerthella lentag+wgs, Enterobacter chengduensiswgs, Enterobacter hormaecheiwgs, Enterocloster clostridioformiswgs, Enterococcus aviump+wgs, Enterococcus faecalisg+p+wgs+gi, Enterococcus faeciumg+p+wgs+gi, Enterococcus hiraeg+p+wgs, Erysipelatoclostridium ramosumwgs, Escherichia colig+p+wgs+gi, Eubacterium limosumwgs, Eubacterium maltosivoransg+gi, Faecalibacterium prausnitziig+wgs, Fusobacterium nucleatumg, Gemella morbillorumg+wgs+gi, Jeotgalibaca arthritidisg, Klebsiella oxytocap, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Lactobacillus crispatusg+wgs+gi, Lactobacillus inersg+wgs+gi, Lactobacillus johnsoniig+wgs, Lactococcus garvieaep, Listeria innocuap, Phocaeicola doreig+wgs, Phocaeicola massiliensiswgs, Phocaeicola vulgatuswgs, Pseudomonas aeruginosawgs, Ruthenibacterium lactatiformanswgs, Salmonella entericag+p+wgs, Shigella boydiiwgs, Shigella flexnerip+wgs, Shigella sonneip+wgs, Staphylococcus arlettaewgs, Staphylococcus aureusg+p+wgs+gi, Staphylococcus epidermidiswgs, Staphylococcus haemolyticuswgs, Staphylococcus pseudintermediusg+wgs+gi, Staphylococcus saprophyticuswgs, Staphylococcus warneriwgs, Streptococcus agalactiaeg+wgs+gi, Streptococcus anginosusg+wgs, Streptococcus caniswgs, Streptococcus constellatuswgs, Streptococcus cristatusg+wgs+gi, Streptococcus dysgalactiaeg+wgs, Streptococcus equiwgs, Streptococcus gallolyticusg+wgs, Streptococcus gordoniig+wgs, Streptococcus gwangjuenseg+gi, Streptococcus iniaep+wgs, Streptococcus intermediusg+wgs, Streptococcus lutetiensisg+wgs, Streptococcus mitiswgs, Streptococcus mutansp+wgs, Streptococcus pasteurianusg+wgs+gi, Streptococcus pneumoniaeg+wgs, Streptococcus porcinuswgs, Streptococcus pseudopneumoniaeg+wgs, Streptococcus pyogenesg+wgs+gi, Streptococcus sanguiniswgs, Streptococcus suisg+p+wgs+gi, Treponema denticolawgs, Vibrio vulnificuswgs |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + ribosomal alteration conferring antibiotic resistance + antibiotic molecule + antibiotic target modifying enzyme + rRNA methyltransferase conferring antibiotic resistance + streptogramin antibiotic [Drug Class] + macrolide antibiotic [Drug Class] + lincosamide antibiotic [Drug Class] + streptogramin A antibiotic [Drug Class] + streptogramin B antibiotic [Drug Class] + 23S ribosomal RNA methyltransferase |
| Parent Term(s) | 25 ontology terms | Show + Erm 23S ribosomal RNA methyltransferase [AMR Gene Family] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic roxithromycin [Antibiotic] + confers_resistance_to_antibiotic telithromycin [Antibiotic] + confers_resistance_to_antibiotic clarithromycin [Antibiotic] + confers_resistance_to_antibiotic tylosin [Antibiotic] + confers_resistance_to_antibiotic spiramycin [Antibiotic] + confers_resistance_to_antibiotic azithromycin [Antibiotic] + confers_resistance_to_antibiotic dirithromycin [Antibiotic] + confers_resistance_to_antibiotic dalfopristin [Antibiotic] + confers_resistance_to_antibiotic griseoviridin [Antibiotic] + confers_resistance_to_antibiotic madumycin II [Antibiotic] + confers_resistance_to_antibiotic virginiamycin M1 [Antibiotic] + confers_resistance_to_antibiotic ostreogrycin B3 [Antibiotic] + confers_resistance_to_antibiotic patricin A [Antibiotic] + confers_resistance_to_antibiotic patricin B [Antibiotic] + confers_resistance_to_antibiotic pristinamycin IA [Antibiotic] + confers_resistance_to_antibiotic pristinamycin IB [Antibiotic] + confers_resistance_to_antibiotic quinupristin [Antibiotic] + confers_resistance_to_antibiotic pristinamycin IC [Antibiotic] + confers_resistance_to_antibiotic vernamycin C [Antibiotic] + confers_resistance_to_antibiotic virginiamycin S2 [Antibiotic] + confers_resistance_to_antibiotic lincomycin [Antibiotic] + confers_resistance_to_antibiotic clindamycin [Antibiotic] + confers_resistance_to_antibiotic oleandomycin [Antibiotic] |
| Publications | Min YH, et al. 2008. Antimicrob Agents Chemother 52(5): 1782-1789. Translational attenuation and mRNA stabilization as mechanisms of erm(B) induction by erythromycin. (PMID 18299414) Yu L, et al. 1997. Nat Struct Biol 4(6): 483-489. Solution structure of an rRNA methyltransferase (ErmAM) that confers macrolide-lincosamide-streptogramin antibiotic resistance. (PMID 9187657) Hajduk PJ, et al. 1999. J Med Chem 42(19): 3852-3859. Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis. (PMID 10508434) |
Prevalence of ErmB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0.18% | 0.05% | 0.01% | 0% |
| Acinetobacter towneri | 0% | 18.75% | 0% | 0% |
| Aliarcobacter butzleri | 12.5% | 33.33% | 0% | 0% |
| Anaerostipes hadrus | 66.67% | 0% | 3.45% | 100% |
| Bacillus subtilis | 1.43% | 0% | 0.58% | 0% |
| Bacillus thuringiensis | 0% | 0.07% | 0.17% | 0% |
| Bacteroides caccae | 0% | 0% | 1.25% | 0% |
| Bacteroides fragilis | 3.85% | 0% | 2.12% | 9.09% |
| Bacteroides ovatus | 6.67% | 0% | 4.18% | 0% |
| Bacteroides thetaiotaomicron | 0% | 0% | 2.1% | 0% |
| Bifidobacterium breve | 0% | 0% | 0.6% | 0% |
| Butyricimonas faecalis | 100% | 0% | 0% | 50% |
| Campylobacter coli | 17.39% | 0% | 2.73% | 20% |
| Campylobacter jejuni | 0.7% | 0% | 0.18% | 0% |
| Citrobacter amalonaticus | 0% | 8.33% | 0% | 0% |
| Citrobacter freundii | 0% | 0% | 0.39% | 0% |
| Citrobacter portucalensis | 0% | 0% | 0.9% | 0% |
| Clostridioides difficile | 0% | 0% | 0% | 16.67% |
| Clostridium butyricum | 0% | 0% | 1.96% | 0% |
| Clostridium perfringens | 0% | 0.97% | 0.73% | 0% |
| Clostridium sporogenes | 0% | 0% | 0% | 100% |
| Collinsella aerofaciens | 0% | 0% | 1.49% | 0% |
| Eggerthella lenta | 10% | 0% | 2.08% | 0% |
| Enterobacter chengduensis | 0% | 0% | 4% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.04% | 0% |
| Enterocloster clostridioformis | 0% | 0% | 6.98% | 0% |
| Enterococcus avium | 0% | 33.33% | 21.05% | 0% |
| Enterococcus faecalis | 15.91% | 25.62% | 23.1% | 20.83% |
| Enterococcus faecium | 3.82% | 15.93% | 34.58% | 1.96% |
| Enterococcus hirae | 7.69% | 19.05% | 12.96% | 0% |
| Erysipelatoclostridium ramosum | 0% | 0% | 11.63% | 0% |
| Escherichia coli | 0.36% | 0.8% | 1.93% | 0.13% |
| Eubacterium limosum | 0% | 0% | 25% | 0% |
| Eubacterium maltosivorans | 100% | 0% | 0% | 100% |
| Faecalibacterium prausnitzii | 33.33% | 0% | 24.27% | 0% |
| Fusobacterium nucleatum | 8.33% | 0% | 0% | 0% |
| Gemella morbillorum | 33.33% | 0% | 25% | 100% |
| Jeotgalibaca arthritidis | 100% | 0% | 0% | 0% |
| Klebsiella oxytoca | 0% | 0.68% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0.49% | 1.2% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.26% | 0% |
| Lactobacillus crispatus | 8% | 0% | 0.27% | 100% |
| Lactobacillus iners | 28.57% | 0% | 3.23% | 40% |
| Lactobacillus johnsonii | 16.67% | 0% | 17.24% | 0% |
| Lactococcus garvieae | 0% | 8.33% | 0% | 0% |
| Listeria innocua | 0% | 10.53% | 0% | 0% |
| Phocaeicola dorei | 9.09% | 0% | 14.58% | 0% |
| Phocaeicola massiliensis | 0% | 0% | 3.85% | 0% |
| Phocaeicola vulgatus | 0% | 0% | 3.9% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.01% | 0% |
| Ruthenibacterium lactatiformans | 0% | 0% | 10% | 0% |
| Salmonella enterica | 0.06% | 0.27% | 0.09% | 0% |
| Shigella boydii | 0% | 0% | 3.33% | 0% |
| Shigella flexneri | 0% | 4.42% | 8.39% | 0% |
| Shigella sonnei | 0% | 2.91% | 1.39% | 0% |
| Staphylococcus arlettae | 0% | 0% | 2.5% | 0% |
| Staphylococcus aureus | 3.14% | 0.56% | 1.85% | 2.01% |
| Staphylococcus epidermidis | 0% | 0% | 0.25% | 0% |
| Staphylococcus haemolyticus | 0% | 0% | 0.22% | 0% |
| Staphylococcus pseudintermedius | 46.67% | 0% | 51.28% | 6.67% |
| Staphylococcus saprophyticus | 0% | 0% | 1.4% | 0% |
| Staphylococcus warneri | 0% | 0% | 1.64% | 0% |
| Streptococcus agalactiae | 17.76% | 0% | 13.21% | 33.33% |
| Streptococcus anginosus | 5.88% | 0% | 6.43% | 0% |
| Streptococcus canis | 0% | 0% | 13.33% | 0% |
| Streptococcus constellatus | 0% | 0% | 4.55% | 0% |
| Streptococcus cristatus | 50% | 0% | 17.14% | 50% |
| Streptococcus dysgalactiae | 2% | 0% | 5.61% | 0% |
| Streptococcus equi | 0% | 0% | 0.68% | 0% |
| Streptococcus gallolyticus | 10% | 0% | 22.73% | 0% |
| Streptococcus gordonii | 7.14% | 0% | 5.13% | 0% |
| Streptococcus gwangjuense | 100% | 0% | 0% | 100% |
| Streptococcus iniae | 0% | 100% | 2.33% | 0% |
| Streptococcus intermedius | 14.29% | 0% | 15.91% | 0% |
| Streptococcus lutetiensis | 14.29% | 0% | 4.08% | 0% |
| Streptococcus mitis | 0% | 0% | 6.06% | 0% |
| Streptococcus mutans | 0% | 33.33% | 0.39% | 0% |
| Streptococcus pasteurianus | 75% | 0% | 50% | 33.33% |
| Streptococcus pneumoniae | 21.84% | 0% | 11.46% | 0% |
| Streptococcus porcinus | 0% | 0% | 33.33% | 0% |
| Streptococcus pseudopneumoniae | 100% | 0% | 11.02% | 0% |
| Streptococcus pyogenes | 5.22% | 0% | 1.49% | 9.09% |
| Streptococcus sanguinis | 0% | 0% | 7.22% | 0% |
| Streptococcus suis | 58.4% | 12.9% | 39.82% | 50% |
| Treponema denticola | 0% | 0% | 11.76% | 0% |
| Vibrio vulnificus | 0% | 0% | 0.41% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400
