| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3000176 |
| Definition | Dirithromycin is an oxazine derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome to inhibit bacterial protein synthesis. |
| SMILES | CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@@H]2N[C@@H](COCCOC)O[C@H]([C@H]2C)[C@]1(C)O |
| PubChem | 6473883 |
| ChEMBL | CHEMBL1237072 |
| ChEBI | 474014 |
| CAS | 62013-04-1 |
| Drug Class | macrolide antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + macrolide antibiotic [Drug Class] |
| Sub-Term(s) | 24 ontology terms | Show + 50S ribosomal subunit P-site targeted_by_antibiotic + ErmC confers_resistance_to_antibiotic + ErmE confers_resistance_to_antibiotic + ErmA confers_resistance_to_antibiotic + ErmB confers_resistance_to_antibiotic + Erm(37) confers_resistance_to_antibiotic + ErmD confers_resistance_to_antibiotic + ErmF confers_resistance_to_antibiotic + ErmG confers_resistance_to_antibiotic + ErmN confers_resistance_to_antibiotic + ErmQ confers_resistance_to_antibiotic + ErmR confers_resistance_to_antibiotic + ErmT confers_resistance_to_antibiotic + ErmX confers_resistance_to_antibiotic + Erm(33) confers_resistance_to_antibiotic + Erm(34) confers_resistance_to_antibiotic + Erm(38) confers_resistance_to_antibiotic + Erm(39) confers_resistance_to_antibiotic + Erm(41) confers_resistance_to_antibiotic + Erm(35) confers_resistance_to_antibiotic + Erm(36) confers_resistance_to_antibiotic + mphA confers_resistance_to_antibiotic + mphB confers_resistance_to_antibiotic + mphC confers_resistance_to_antibiotic |
| Publications | Mazzei T, et al. 1993. J Antimicrob Chemother 31(SUPPL C): 1-9. Chemistry and mode of action of macrolides. (PMID 7683018) |
| Curator | Description | Most Recent Edit |
|---|
