dirithromycin [Antibiotic]

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Accession ARO:3000176
DefinitionDirithromycin is an oxazine derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome to inhibit bacterial protein synthesis.
Drug Classmacrolide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ macrolide antibiotic [Drug Class]
Sub-Term(s)
27 ontology terms | Show
+ 50S ribosomal subunit P-site targeted_by_antibiotic
+ ErmC confers_resistance_to_antibiotic
+ ErmC' confers_resistance_to_antibiotic
+ ErmE confers_resistance_to_antibiotic
+ ErmA confers_resistance_to_antibiotic
+ ErmB confers_resistance_to_antibiotic
+ Erm(37) confers_resistance_to_antibiotic
+ ErmD confers_resistance_to_antibiotic
+ ErmF confers_resistance_to_antibiotic
+ ErmG confers_resistance_to_antibiotic
+ ErmI confers_resistance_to_antibiotic
+ ErmN confers_resistance_to_antibiotic
+ ErmQ confers_resistance_to_antibiotic
+ ErmR confers_resistance_to_antibiotic
+ ErmT confers_resistance_to_antibiotic
+ ErmX confers_resistance_to_antibiotic
+ Erm(31) confers_resistance_to_antibiotic
+ Erm(33) confers_resistance_to_antibiotic
+ Erm(34) confers_resistance_to_antibiotic
+ Erm(38) confers_resistance_to_antibiotic
+ Erm(39) confers_resistance_to_antibiotic
+ Erm(41) confers_resistance_to_antibiotic
+ Erm(35) confers_resistance_to_antibiotic
+ Erm(36) confers_resistance_to_antibiotic
+ mphA confers_resistance_to_antibiotic
+ mphB confers_resistance_to_antibiotic
+ mphC confers_resistance_to_antibiotic
Publications

Mazzei T, et al. 1993. J Antimicrob Chemother 31(SUPPL C): 1-9. Chemistry and mode of action of macrolides. (PMID 7683018)