| Accession | ARO:3000319 |
| CARD Short Name | mphC |
| Definition | The mphC gene was identified from Staphylococcus aureus. This gene shows similarity to mphB gene from Escherchia coli. |
| AMR Gene Family | macrolide phosphotransferase (MPH) |
| Drug Class | macrolide antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Listeria monocytogeneswgs, Staphylococcus arlettaeg+wgs, Staphylococcus aureusg+p+wgs, Staphylococcus capitisg+wgs, Staphylococcus epidermidisg+p+wgs, Staphylococcus equorumg+p+wgs, Staphylococcus haemolyticusg+p+wgs, Staphylococcus hominisp+wgs, Staphylococcus massiliensiswgs, Staphylococcus saprophyticusp+wgs, Staphylococcus warneriwgs |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic molecule + antibiotic inactivation enzyme + macrolide antibiotic [Drug Class] + phosphorylation of antibiotic conferring resistance + macrolide inactivation enzyme |
| Parent Term(s) | 10 ontology terms | Show + macrolide phosphotransferase (MPH) [AMR Gene Family] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic roxithromycin [Antibiotic] + confers_resistance_to_antibiotic telithromycin [Antibiotic] + confers_resistance_to_antibiotic clarithromycin [Antibiotic] + confers_resistance_to_antibiotic tylosin [Antibiotic] + confers_resistance_to_antibiotic spiramycin [Antibiotic] + confers_resistance_to_antibiotic azithromycin [Antibiotic] + confers_resistance_to_antibiotic dirithromycin [Antibiotic] + confers_resistance_to_antibiotic oleandomycin [Antibiotic] |
| Publications | Matsuoka M, et al. 2003. FEMS Microbiol Lett 220(2): 287-293. Characteristic expression of three genes, msr(A), mph(C) and erm(Y), that confer resistance to macrolide antibiotics on Staphylococcus aureus. (PMID 12670694) Chesneau O, et al. 2007. FEMS Microbiol Lett 269(2): 317-322. Resistance phenotypes conferred by macrolide phosphotransferases. (PMID 17302923) Pawlowski AC, et al. 2018. Nat Commun 9(1):112 The evolution of substrate discrimination in macrolide antibiotic resistance enzymes. (PMID 29317655) |
Prevalence of mphC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Listeria monocytogenes | 0% | 0% | 0.05% | 0% |
| Staphylococcus arlettae | 16.67% | 0% | 22.5% | 0% |
| Staphylococcus aureus | 2.53% | 3.57% | 8.58% | 0% |
| Staphylococcus capitis | 10% | 0% | 0.63% | 0% |
| Staphylococcus epidermidis | 3.23% | 2.02% | 14.06% | 0% |
| Staphylococcus equorum | 33.33% | 5.41% | 41.07% | 0% |
| Staphylococcus haemolyticus | 31.03% | 1.89% | 31.43% | 0% |
| Staphylococcus hominis | 0% | 4.17% | 15.12% | 0% |
| Staphylococcus massiliensis | 0% | 0% | 14.29% | 0% |
| Staphylococcus saprophyticus | 0% | 5.41% | 11.89% | 0% |
| Staphylococcus warneri | 0% | 0% | 3.28% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500