| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:0000057 |
| Synonym(s) | HMR-3647 HMR3647 Ketek Levviax |
| Definition | Telithromycin is a semi-synthetic derivative of erythromycin. It is a 14-membered macrolide and is the first ketolide antibiotic to be used in clinics. Telithromycin binds the 50S subunit of the bacterial ribosome to inhibit protein synthesis. |
| SMILES | CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C |
| PubChem | 3002190 |
| ChEMBL | CHEMBL1136 |
| ChEBI | 29688 |
| CAS | 191114-48-4 |
| Drug Class | macrolide antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + macrolide antibiotic [Drug Class] |
| Sub-Term(s) | 31 ontology terms | Show + 50S ribosomal subunit P-site targeted_by_antibiotic + mel confers_resistance_to_antibiotic + ErmC confers_resistance_to_antibiotic + ErmE confers_resistance_to_antibiotic + ErmA confers_resistance_to_antibiotic + ErmB confers_resistance_to_antibiotic + Erm(37) confers_resistance_to_antibiotic + ErmD confers_resistance_to_antibiotic + ErmF confers_resistance_to_antibiotic + ErmG confers_resistance_to_antibiotic + ErmN confers_resistance_to_antibiotic + ErmQ confers_resistance_to_antibiotic + ErmR confers_resistance_to_antibiotic + ErmT confers_resistance_to_antibiotic + ErmX confers_resistance_to_antibiotic + Erm(33) confers_resistance_to_antibiotic + Erm(34) confers_resistance_to_antibiotic + Erm(38) confers_resistance_to_antibiotic + Erm(39) confers_resistance_to_antibiotic + Erm(41) confers_resistance_to_antibiotic + Erm(35) confers_resistance_to_antibiotic + Erm(36) confers_resistance_to_antibiotic + mphA confers_resistance_to_antibiotic + mphB confers_resistance_to_antibiotic + mphC confers_resistance_to_antibiotic + Escherichia coli 23S rRNA with mutation conferring resistance to erythromycin and telithromycin confers_resistance_to_antibiotic + Mycoplasma hominis 23S rRNA with mutation conferring resistance to macrolide antibiotics confers_resistance_to_antibiotic + mphJ confers_resistance_to_antibiotic + mphI confers_resistance_to_antibiotic + mphK confers_resistance_to_antibiotic + Enterobacter cloacae rob confers_resistance_to_antibiotic |
| Publications | Katz L and Ashley GW. 2005. Chem Rev 105(2): 499-528. Translation and protein synthesis: macrolides. (PMID 15700954) |
| Curator | Description | Most Recent Edit |
|---|
