| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3000145 |
| Definition | Tylosin is a 16-membered macrolide, naturally produced by Streptomyces fradiae. It interacts with the bacterial ribosome 50S subunit to inhibit protein synthesis. |
| SMILES | CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC |
| PubChem | 5280440 |
| ChEMBL | CHEMBL42743 |
| ChEBI | 17658 |
| CAS | 1401-69-0 |
| Drug Class | macrolide antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + macrolide antibiotic [Drug Class] |
| Sub-Term(s) | 41 ontology terms | Show + 50S ribosomal subunit P-site targeted_by_antibiotic + ErmC confers_resistance_to_antibiotic + ErmE confers_resistance_to_antibiotic + ErmA confers_resistance_to_antibiotic + ErmB confers_resistance_to_antibiotic + Erm(37) confers_resistance_to_antibiotic + ErmD confers_resistance_to_antibiotic + ErmF confers_resistance_to_antibiotic + ErmG confers_resistance_to_antibiotic + ErmN confers_resistance_to_antibiotic + ErmQ confers_resistance_to_antibiotic + ErmR confers_resistance_to_antibiotic + ErmT confers_resistance_to_antibiotic + ErmX confers_resistance_to_antibiotic + Erm(33) confers_resistance_to_antibiotic + Erm(34) confers_resistance_to_antibiotic + Erm(38) confers_resistance_to_antibiotic + Erm(39) confers_resistance_to_antibiotic + Erm(41) confers_resistance_to_antibiotic + Erm(35) confers_resistance_to_antibiotic + Erm(36) confers_resistance_to_antibiotic + oleD confers_resistance_to_antibiotic + mgtA confers_resistance_to_antibiotic + gimA confers_resistance_to_antibiotic + mphB confers_resistance_to_antibiotic + mphC confers_resistance_to_antibiotic + Brachyspira hyodysenteriae 23S rRNA with mutation conferring resistance to tylosin confers_resistance_to_antibiotic + Streptococcus pneumoniae 23S rRNA mutation conferring resistance to macrolides and streptogramins antibiotics confers_resistance_to_antibiotic + tlrC confers_resistance_to_antibiotic + Erm(O)-lrm confers_resistance_to_antibiotic + ErmS confers_resistance_to_antibiotic + ErmV confers_resistance_to_antibiotic + Mycoplasma hominis 23S rRNA with mutation conferring resistance to macrolide antibiotics confers_resistance_to_antibiotic + RlmA(II) confers_resistance_to_antibiotic + chrB confers_resistance_to_antibiotic + mphJ confers_resistance_to_antibiotic + mphF confers_resistance_to_antibiotic + mphI confers_resistance_to_antibiotic + myrA confers_resistance_to_antibiotic + tlrB conferring tylosin resistance confers_resistance_to_antibiotic + Mrx confers_resistance_to_antibiotic |
| Publications | Blackwood RS, et al. 2008. Comp Med 58(1): 81-87. Effects of the macrolide drug tylosin on chronic diarrhea in rhesus macaques (Macaca mulatta). (PMID 19793461) |
| Curator | Description | Most Recent Edit |
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