tylosin [Antibiotic]

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Accession ARO:3000145
DefinitionTylosin is a 16-membered macrolide, naturally produced by Streptomyces fradiae. It interacts with the bacterial ribosome 50S subunit to inhibit protein synthesis.
Drug Classmacrolide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ macrolide antibiotic [Drug Class]
Sub-Term(s)
31 ontology terms | Show
+ 50S ribosomal subunit P-site targeted_by_antibiotic
+ ErmC confers_resistance_to_antibiotic
+ ErmC' confers_resistance_to_antibiotic
+ ErmE confers_resistance_to_antibiotic
+ ErmA confers_resistance_to_antibiotic
+ ErmB confers_resistance_to_antibiotic
+ Erm(37) confers_resistance_to_antibiotic
+ ErmD confers_resistance_to_antibiotic
+ ErmF confers_resistance_to_antibiotic
+ ErmG confers_resistance_to_antibiotic
+ ErmI confers_resistance_to_antibiotic
+ ErmN confers_resistance_to_antibiotic
+ ErmQ confers_resistance_to_antibiotic
+ ErmR confers_resistance_to_antibiotic
+ ErmT confers_resistance_to_antibiotic
+ ErmX confers_resistance_to_antibiotic
+ Erm(31) confers_resistance_to_antibiotic
+ Erm(33) confers_resistance_to_antibiotic
+ Erm(34) confers_resistance_to_antibiotic
+ Erm(38) confers_resistance_to_antibiotic
+ Erm(39) confers_resistance_to_antibiotic
+ Erm(41) confers_resistance_to_antibiotic
+ Erm(35) confers_resistance_to_antibiotic
+ Erm(36) confers_resistance_to_antibiotic
+ oleD confers_resistance_to_antibiotic
+ mgtA confers_resistance_to_antibiotic
+ gimA confers_resistance_to_antibiotic
+ mphB confers_resistance_to_antibiotic
+ mphC confers_resistance_to_antibiotic
+ Brachyspira hyodysenteriae 23S rRNA with mutation conferring resistance to tylosin confers_resistance_to_antibiotic
+ Streptococcus pneumoniae 23S rRNA mutation conferring resistance to macrolides and streptogramins antibiotics confers_resistance_to_antibiotic
Publications

Blackwood RS, et al. 2008. Comp Med 58(1): 81-87. Effects of the macrolide drug tylosin on chronic diarrhea in rhesus macaques (Macaca mulatta). (PMID 19793461)