Brachyspira hyodysenteriae 23S rRNA with mutation conferring resistance to tylosin

Accession ARO:3004133
CARD Short NameBhyo_23S_TYL
DefinitionPoint mutation in B. hyodysenteriae 23S rRNA shown to confer resistance to tylosin and erythromycin.
AMR Gene Family23S rRNA with mutation conferring resistance to macrolide antibiotics
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic target alteration
Classification10 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tylosin [Antibiotic]
+ 23S rRNA with mutation conferring resistance to macrolide antibiotics [AMR Gene Family]
Publications

Vester B, et al. 2001. Antimicrob. Agents Chemother. 45(1):1-12 Macrolide resistance conferred by base substitutions in 23S rRNA. (PMID 11120937)

Resistomes

Prevalence of Brachyspira hyodysenteriae 23S rRNA with mutation conferring resistance to tylosin among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: rRNA gene variant model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: rRNA gene variant model

Model Definition: Ribosomal RNA (rRNA) Gene Variant Models (RVM) are similar to Protein Variant Models (PVM), i.e. detect sequences based on their similarity to a curated reference sequence and secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles, except RVMs are designed to detect AMR acquired via mutation of genes encoding ribosomal RNAs (rRNA). RVMs include a rRNA reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTN bit-score above the curated BLASTN cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTN bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastN): 2000

Legend:

  • discovered in clinical, agricultural, or environmental isolates

  • discovered via laboratory selection experiments

  • ReSeqTB https://platform.reseqtb.org

Published Variants:

PMID: 11120937A2058G A2058T


>gb|NZ_CP015910.2|-|2512813-2515808|Brachyspira hyodysenteriae 23S rRNA with mutation conferring resistance to tylosin [Brachyspira hyodysenteriae ATCC 27164]
ATATGGTCAAGTCATTGGTCTGATTAGTGCTGCTCAGCTGAACAGGTATTTCTTCCCTGCTTACACTTGCAGTCTATCAACGTCGTAGTC
TCCAACGAAACTCATAGGGAAAGTTAATCTTGAAGGAGGCTTCCCACTTAGATGCTTTCAGCGGTTATCCCGTCCGCACATAGCTACTCT
GCGATGCTCTTGGCAGAACAACAGATACACCAGCGGTGCGTTCATTCCGGTCCTCTCGTACTAAGAATGACTCTTCTCAACTTTCCAACG
CCCACAACGGATAGGGACCAAACTGTCTCACGACGTTCTGAACCCAGCTCGCGTACCGCTTTAATTGGCGAACAGCCAAACCCTTGGGAC
CTGCTCCAGCCCCAGGATGCGATGAGCCGACATCGAGGTGCCAAACCTCCCCGTCGATATGAACTCTTGGGGGAGATAAGCCTGTTATCC
CCGGAGTACCTTTTGTCCGTTTAGCGATGGCCCTTCCACTCGGGACCACCGGATCACTAAAACCTACTTTCGTACCTGCTCGAGATGTCT
CTCTCGCAGTCAAGCCACCTTATGCCTTTATACTCTACTACCGATTTCTATTCGGTTTGAGGTGACCTTTGCACGCCTCCGTTACTCTTT
AGGAGGCGACCGCCCCAGTCAAACTACCCGCCTGACAATGTCCGACTGCCGGATAACGGCTAATCGTTAGAATCCCATTTTGCGAAGGAT
GGTATTTCAACGATGGCTCCATGAAAGCTGGCGCTCCCACTTCAAAGCCTCCCATCTATCCTACACATCACAAAACAAAACTCAATGTCA
AGTTATAGTAAAGGTTCACGGGGTCTTTCCGTCCTGTTGCGGGTAATCAGCATCTTCACTGATAATTCAATTTCACCGAGTTCTTCCCCG
AGACAGTGCCCGGATCGTTACACCATTCGTGCAGGTCGGAACTTACCCGACAAGGAATTTCGCTACCTTAGGACCGTCATAGTTACGGCC
GCCGTTTACTGGGGCTTCAATTCGAAGCTTCGCTTACGCTAACCTCTCCTTTTAACCTTCCAGCACTGGGCAGGTGTCAATCCCTATACA
TCCATTTACATGTTTGCAGAGATCTGTGTTTTTGTTAAACAGTCGGCCAGGCCTTTTCACTGCGACTCTCCTCTCAATATTGCTACCAAG
ATTCAAGCGTCTCTTTTTCCGAAGTTACAAGACTAATTTGCAGAGTTCCTTAGGGAAGATTATCTCGAGCGCCTTAGAATACTCATCTCA
CCCACCTGTGTCGGTTTGCGGTACGATTATGACATGCCTAACCTTAGAAATTATTTCTCGACAGCCTAGCTCATGCAACTTCCTGAACCC
GAAAGCCCAGTCACTATCCAGCCTCAACCTTAAAGAAGCAAGCATTTGACTCACCTCAAGTCTAAACTGTTTGACGTTATCTACCAATCT
AACGCGTACATAAACAATCTGTGTCATTCCATCGAAACATATCATAGTACAGGAATATTTACCTGTTTCCCATCGACTACGCTTTTCAGC
CTCATCTTAGGGGTCGACTAACCCTAGGCAGATTAGCTTTACCTAGGAAACCTTGGGTTTGCGGCGAACGGGTTTCTCACCCGTTTTCTC
GTTACTCATGCCTGCATCCTCACTTCTTATACCTCCAGCCCACCTCACGATGAACCTTCGACGGCTTAAAGAACGCTCTCCTACCAATTA
TAGATTAACTCTATAATTCCCTAGCTTCGGTACTATGTTTGAGCCCCGTTACATTTTCGGCGCAAGAACACTCGACCAGTGAGCTGTTAC
GCACTCTTTAAAGGAATGGCTGCTTCTAAGCCAACCTCCTGGCTGTTTAAGTATTCTCACATCCTTTCCCACTTAACATAGATTTTGGGA
CCTTAGCTGAGGATCTGGGCTGTTTCCCTTTTGACAATGACGCTTATCCGCCGCTGTCTAACTGCCATGTTCTTAACTTACGGTATTCGG
AGTTTAGTTGGGTTTGGTACTCGGTTAGGAGCCCTAGTCCATTTAGTGCTCTACCCCCGCAAGTAAACACATAACGCTGCCCCTAAAGAC
ATTTCGGAGAGAACCAGCTATCTCCAAGTTTGATTAGCCTTTCACTCCTACCCACAAGTCATCCAAAGCCTTTTCACGGCCACTGGTTCG
CACCTCCATTCGATGTTACTCGAGTTTCGCGCTGCTCATAGGTAGATCACTTGGCTTCGGGTCGTATAGCATGCAACTAATTTCGCCCTA
TTAAGGCTCGCTTTCACTACGACTACAAGGCTATTACCTCTTAATCTTGCTACATACTATAAGTCGCAGGCTCATTCTACAAAAGGCACG
CCATCAGGCCATCTACTATTGCTAGCAGGGTACCCTCTGACTACTTGTAAGCTTAAGGTTTCAGGTTCTATTTAATAACCCTCAACGGGA
GACTTTTCACCTTTCCCTCACGGTACTCTACACTATTGGTCACTGGTTAGTATTTTGCCTTGGATAGTGGTCTACCCAGATTCAAACAGG
GTTTCACGTGCCCCGCCCTACTCAGGAACGATAAAACCTTGTCTATATGATTTCGTGTACAGGACTATCACCCACTATGGTCTGCTTTTC
CAAAACAGTTCCACTATCATATAAAGCAAAGTCGATGCATGCAAGTACATCGCTTACCGCCCTACAACACCATAATAACAACGCCTTGCA
GCTTGACATTATTAAGGTTTAGGCTCTTCCCCTTTCGCTCGCCACTACTTAGGGAATCTCAATTTTGATTACTCTTCCTCCAGGTACTTA
GATGTTTCAGTTCCCTGGGTGTCGCCTCATACACCTATGGATTCAGTGTATGATATAGAAGGTTTACTTCTATAGGTTTTCCCATTCGGT
GATCTACGGATCATAGAATATTTGCTTCTCCCCGTAGCTTATCGCAGCTTGTCACGACCTTCATCGCCTTCCAGTGCCTAGGCATCCACC
TTAAGCCCTTACTTACTTGACCATAT