| Accession | ARO:3002824 |
| Synonym(s) | ermSV |
| CARD Short Name | ErmV |
| Definition | ErmV is a plasmid-mediated methyltransferase found in Streptomyces viridochromogenes. |
| AMR Gene Family | Erm 23S ribosomal RNA methyltransferase |
| Drug Class | macrolide antibiotic, lincosamide antibiotic, streptogramin antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + antibiotic target modifying enzyme + ribosomal alteration conferring antibiotic resistance + antibiotic molecule + rRNA methyltransferase conferring antibiotic resistance + macrolide antibiotic [Drug Class] + lincosamide antibiotic [Drug Class] + 23S ribosomal RNA methyltransferase + streptogramin antibiotic [Drug Class] |
| Parent Term(s) | 8 ontology terms | Show + Erm 23S ribosomal RNA methyltransferase [AMR Gene Family] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic oleandomycin [Antibiotic] + confers_resistance_to_antibiotic celesticetin [Antibiotic] + confers_resistance_to_antibiotic carbomycin [Antibiotic] + confers_resistance_to_antibiotic chalcomycin [Antibiotic] + confers_resistance_to_antibiotic kitasamycin [Antibiotic] + confers_resistance_to_antibiotic tylosin [Antibiotic] |
| Publications | Fujisawa Y and Weisblum B. 1981. J Bacteriol 146(2): 621-631. A family of r-determinants in Streptomyces spp. that specifies inducible resistance to macrolide, lincosamide, and streptogramin type B antibiotics. (PMID 6163765) Kamimiya S, et al. 1997. Antimicrob Agents Chemother 41(3):530-4 Induction of ermSV by 16-membered-ring macrolide antibiotics. (PMID 9055987) |
Prevalence of ErmV among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400