gimA

Accession ARO:3000463
CARD Short NamegimA
DefinitionA macrolide glycosyltransferase encoded by the gimA gene in Streptomyces ambofaciens, a natural producer of the macrolide antibiotic spiramycin. Chalcomycin, methymycin, tylosin, pikromycin, rosaramicin, oleandomycin, josamycin, and carbomycin are preferred substrates of gimA glycosyltransferase, while erythromycin and spiramycin have notably low binding affinities. GimA may be able to inactivate spiramycin precursors. Described by Gourmelen et al. 1998.
AMR Gene FamilygimA family macrolide glycosyltransferase
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic inactivation
Classification10 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ confers_resistance_to_antibiotic tylosin [Antibiotic]
+ confers_resistance_to_antibiotic oleandomycin [Antibiotic]
+ confers_resistance_to_antibiotic chalcomycin [Antibiotic]
+ confers_resistance_to_antibiotic methymycin [Antibiotic]
+ gimA family macrolide glycosyltransferase [AMR Gene Family]
Publications

Gourmelen A, et al. 1998. Antimicrob Agents Chemother 42(10): 2612-2619. Characterization of a glycosyl transferase inactivating macrolides, encoded by gimA from Streptomyces ambofaciens. (PMID 9756764)

Resistomes

Prevalence of gimA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 700


>gb|CAA11707.1|+|gimA [Streptomyces ambofaciens]
MRRGDLHETYRLDYAPHMHDPAHIAMFSIAAHGHVNPSLEVIRELVARGHRVTYAIPPLFAEKVAETGAEPKLWNSTLPGPDADPDAWGT
TPLDNVEPFLDDAIQALPQLIAAYEGDEPDLVLHDITSYPARVLAHRWGVPAVSLSPNLVAWEGYEEEVGRPTWEEPLKTERGRAYDARF
RGWLKENGITEDPDPFVGRPDRSLVLIPKALQPHADRVDEKTHTFVGACQGDRAAEGDWRRPEGAEKVVLVSLGSSFTKRPAFYRACVEA
FGALPGWHVVLQVGRHVDPAELGDVPENVEVRSWVPQLAILKQADLFVTHAGAGGSQEGLATATPIVAVPQAVDQFGNADMLQGLGVGRH
LPTEEATAEALRAAGLALVEDPEVARRLKEIQAGMAREGGTRRAADLIEAELAAART


>gb|AJ223970.1|+|797-2050|gimA [Streptomyces ambofaciens]
GTGAGAAGAGGTGATTTGCACGAGACGTATCGTCTTGATTACGCTCCGCACATGCACGATCCCGCTCATATCGCGATGTTCTCCATCGCC
GCGCACGGTCACGTGAACCCCAGCCTGGAAGTGATCCGGGAACTCGTCGCGCGAGGGCACCGGGTGACCTACGCGATCCCGCCGCTCTTC
GCCGAGAAGGTCGCCGAGACGGGCGCCGAACCCAAGCTGTGGAACAGCACGCTGCCCGGCCCCGACGCCGACCCGGACGCGTGGGGGACC
ACACCGCTGGACAACGTCGAGCCGTTCCTCGACGACGCGATCCAGGCGCTCCCGCAGCTCATCGCGGCGTACGAGGGCGACGAGCCGGAC
CTGGTCCTGCACGACATCACCTCCTACCCGGCCCGCGTCCTCGCCCATCGCTGGGGCGTTCCCGCCGTCTCGCTCTCGCCGAACCTGGTC
GCCTGGGAGGGGTACGAGGAGGAGGTCGGCCGGCCGACGTGGGAGGAGCCGCTGAAGACCGAGCGCGGCCGGGCGTACGACGCCCGCTTC
CGTGGCTGGCTGAAGGAGAACGGGATCACCGAGGACCCCGACCCCTTCGTCGGCCGTCCCGACCGGTCGCTGGTCCTCATCCCGAAGGCG
CTCCAGCCGCACGCCGACCGGGTCGACGAGAAGACGCACACCTTCGTCGGTGCCTGCCAGGGCGACCGCGCCGCCGAGGGCGACTGGCGG
CGTCCGGAGGGCGCGGAGAAGGTCGTCCTCGTCTCGCTCGGGTCCTCGTTCACCAAGCGGCCGGCGTTCTACCGGGCGTGCGTCGAGGCG
TTCGGCGCGCTGCCCGGCTGGCACGTGGTGCTCCAGGTCGGCCGGCACGTCGACCCCGCCGAGCTGGGCGACGTACCGGAGAACGTGGAG
GTCCGCTCCTGGGTGCCGCAGCTGGCGATCCTGAAGCAGGCTGACCTGTTCGTCACGCACGCGGGCGCGGGCGGCAGCCAGGAGGGCCTC
GCCACCGCCACGCCGATAGTGGCGGTACCGCAGGCGGTGGACCAGTTCGGCAACGCGGACATGCTCCAGGGGCTCGGCGTGGGCCGCCAC
CTGCCCACCGAGGAAGCCACCGCCGAGGCGCTGCGCGCCGCCGGGCTCGCCCTGGTCGAGGACCCGGAGGTGGCCCGGCGGCTGAAGGAG
ATCCAGGCCGGGATGGCCCGGGAGGGCGGCACCCGGCGGGCCGCCGACCTGATCGAGGCGGAGCTGGCGGCGGCGAGGACCTGA