Ontology | CARD's Antibiotic Resistance Ontology |
Accession | ARO:3000458 |
Definition | Macrolide glycosyltransferases are enzymes encoded by macrolide glycosyltransferase genes and inactivate macrolides by glycosylating them at 2'-OH of desosamine sugar moiety. They are predominantly found in macrolide producers and are also found in non-producers and are used as a resistance mechanism. Different variants of this enzyme has been reported. |
Resistance Mechanism | antibiotic inactivation |
Classification | 5 ontology terms | Show |
Parent Term(s) | 2 ontology terms | Show |
Sub-Term(s) | 3 ontology terms | Show + ole glycosyltransferase [AMR Gene Family] + gimA family macrolide glycosyltransferase [AMR Gene Family] + mgt macrolide glycotransferase [AMR Gene Family] |
Publications | Bolam DN, et al. 2007. Proc Natl Acad Sci U S A 104(13): 5336-5341. The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity. (PMID 17376874) |
Curator | Description | Most Recent Edit |
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