ole glycosyltransferase [AMR Gene Family]

Accession ARO:3000465
DefinitionOleI and OleD are glycosyltransferases found in Streptomyces antibioticus which is a natural producer of antibiotic oleandomycin. OleI glycosylates antibiotic oleandomycin whereas OleD can glycosylate a wide variety of macrolides.
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic inactivation
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ macrolide glycosyltransferase
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
2 ontology terms | Show
+ oleD
+ oleI

Yang M, et al. 2005. J Am Chem Soc 127(26): 9336-9337. Probing the breadth of macrolide glycosyltransferases: in vitro remodeling of a polyketide antibiotic creates active bacterial uptake and enhances potency. (PMID 15984838)

Bolam DN, et al. 2007. Proc Natl Acad Sci U S A 104(13): 5336-5341. The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity. (PMID 17376874)

Quiros LM, et al. 1998. Mol Microbiol 28(6): 1177-1185. Two glycosyltransferases and a glycosidase are involved in oleandomycin modification during its biosynthesis by Streptomyces antibioticus. (PMID 9680207)