macrolide phosphotransferase (MPH) [AMR Gene Family]

Accession ARO:3000333
DefinitionMacrolide phosphotransferases (MPH) are enzymes encoded by macrolide phosphotransferase genes (mph genes). These enzymes phosphorylate macrolides in GTP dependent manner at 2'-OH of desosamine sugar thereby inactivating them. Characterized MPH's are differentiated based on their substrate specificity.
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic inactivation
Classification6 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ macrolide inactivation enzyme
+ participates_in phosphorylation of antibiotic conferring resistance
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
15 ontology terms | Show
+ mphC
+ mphB
+ mphA
+ mphF
+ mphL
+ mphH
+ mphN
+ mphJ
+ mphK
+ mphO
+ mphG
+ mphE
+ mphM
+ Mrx
+ mphI