linezolid [Antibiotic]

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Accession ARO:0000072
Synonym(s)Zyvoxam Zyvox Zyvoxid Zyvoxa
DefinitionLinezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics. It inhibits protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes.
Drug Classoxazolidinone antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
11 ontology terms | Show
+ 50S ribosomal subunit P-site targeted_by_antibiotic
+ cfr(B) confers_resistance_to_antibiotic
+ Staphylococcus aureus LmrS confers_resistance_to_antibiotic
+ clcD confers_resistance_to_antibiotic
+ 23S rRNA with mutation conferring resistance to linezolid antibiotics [AMR Gene Family] confers_resistance_to_antibiotic
+ poxtA confers_resistance_to_antibiotic
+ optrA confers_resistance_to_antibiotic
+ Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics confers_resistance_to_antibiotic
+ cfr(D) confers_resistance_to_antibiotic
+ Staphylococcus aureus 23S rRNA with mutation conferring resistance to linezolid confers_resistance_to_antibiotic
+ YajC confers_resistance_to_antibiotic

Wilson DN, et al. 2008. Proc Natl Acad Sci U S A 105(36): 13339-13344. The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning. (PMID 18757750)

Mukhtar TA and Wright GD. 2005. Chem Rev 105(2): 529-542. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (PMID 15700955)