| Accession | ARO:0000072 |
| Synonym(s) | Zyvox Zyvoxa Zyvoxam Zyvoxid |
| Definition | Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics. It inhibits protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. |
| Drug Class | oxazolidinone antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + oxazolidinone antibiotic [Drug Class] |
| Sub-Term(s) | 11 ontology terms | Show + 50S ribosomal subunit P-site targeted_by_antibiotic + cfr(B) confers_resistance_to_antibiotic + Staphylococcus aureus LmrS confers_resistance_to_antibiotic + clcD confers_resistance_to_antibiotic + 23S rRNA with mutation conferring resistance to linezolid antibiotics [AMR Gene Family] confers_resistance_to_antibiotic + poxtA confers_resistance_to_antibiotic + optrA confers_resistance_to_antibiotic + Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics confers_resistance_to_antibiotic + cfr(D) confers_resistance_to_antibiotic + Staphylococcus aureus 23S rRNA with mutation conferring resistance to linezolid confers_resistance_to_antibiotic + YajC confers_resistance_to_antibiotic |
| Publications | Wilson DN, et al. 2008. Proc Natl Acad Sci U S A 105(36): 13339-13344. The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning. (PMID 18757750) Mukhtar TA and Wright GD. 2005. Chem Rev 105(2): 529-542. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (PMID 15700955) |
