poxtA

Accession ARO:3004470
CARD Short NamepoxtA
DefinitionPoxtA is an ABC-F subfamily ATP-binding cassette protein that confers resistance to tetracycline, -phenicol, and oxazolidinone via modification of the bacterial ribosome. The encoding gene was isolated from a methicillin-resistant Staphylococcus aureus strain.
AMR Gene FamilyMiscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins
Drug Classphenicol antibiotic, tetracycline antibiotic, oxazolidinone antibiotic
Resistance Mechanismantibiotic target protection
Resistomes with Perfect MatchesEnterococcus faecalisg+p+wgs, Enterococcus faeciump+wgs, Enterococcus hiraep+wgs, Staphylococcus aureusg+wgs, Staphylococcus saprophyticuswgs
Resistomes with Sequence VariantsBlautia productag+wgs, Enterocloster clostridioformisg+wgs, Enterococcus faecalisg+p+wgs, Enterococcus faeciump+wgs, Enterococcus hiraep+wgs, Roseburia hominiswgs, Staphylococcus aureusg+wgs, Staphylococcus saprophyticuswgs
Classification10 ontology terms | Show
Parent Term(s)6 ontology terms | Show
+ confers_resistance_to_antibiotic linezolid [Antibiotic]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic florfenicol [Antibiotic]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic doxycycline [Antibiotic]
+ Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins [AMR Gene Family]
Publications

Antonelli A, et al. 2018. J. Antimicrob. Chemother. : Characterization of poxtA, a novel phenicol-oxazolidinone-tetracycline resistance gene from an MRSA of clinical origin. (PMID 29635422)

Resistomes

Prevalence of poxtA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Blautia producta100%0%54.55%0%
Enterocloster clostridioformis100%0%55.81%0%
Enterococcus faecalis0.91%3.94%0.49%0%
Enterococcus faecium0%3.04%2.54%0%
Enterococcus hirae0%21.43%2.78%0%
Roseburia hominis0%0%11.11%0%
Staphylococcus aureus0.09%0%0.01%0%
Staphylococcus saprophyticus0%0%0.7%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 300


>gb|AVI44920.1|-|poxtA [Staphylococcus aureus]
MKGKNMNLAFGLEEIYEDAEFQIGDLDKVGIVGVNGAGKTTLFRLLLGELELDNGSLTSGNARIGYLPQEIVLEDEDITVWDFLFEGRPI
KKYEQELEEIYKKLETAVNAEQEALLARMGTLQERLEYFDFYEAETILLEFADKMSIDAELYHRPMRELSGGQKSKMAFARLLYSKPEIL
LLDEPTNHLDVSTKDFVIKYLKNYRGSVLIISHDIDFLNRIINKIMYINKATHKISVYDGDYYIYKKKYAEEQRIREMAIVQQEKEIKEL
SDFVQKAKQASQTNHHLKRMGQERALRLDKKRGELQKRNRLYKRVKMDIRPKREGAQVPLEVENITFHYSGYPTLYQNLSFQINGRERFL
VVGENGVGKSTLLKLMMGILSPDEGCIRFNQKTDIAYYAQELEQLDENKTVIDNVESEGYTPWQIRAVLSNFLFYDDDVNKKVSVLSPGE
KARVALCKILLQKANLLILDEPTNHLDPETQKIIGGNFNLFEGTIIAVSHNPSFVEQIGISRMLILPSGRIEPYSRELLEYYYEINGSVA
KF


>gb|MF095097.1|-|1856-3484|poxtA [Staphylococcus aureus]
ATGAAAGGTAAAAATATGAATTTAGCCTTTGGGTTGGAAGAAATTTATGAGGATGCTGAGTTTCAAATCGGAGATTTGGATAAGGTCGGT
ATTGTCGGCGTGAACGGAGCCGGAAAGACCACCTTGTTCCGCCTGCTGTTGGGAGAACTTGAACTTGATAATGGTTCACTGACCAGTGGA
AATGCCCGTATTGGTTATCTCCCACAGGAAATTGTCTTGGAAGATGAGGATATTACCGTTTGGGATTTCCTTTTTGAGGGACGTCCGATT
AAAAAGTATGAGCAGGAATTGGAAGAAATCTATAAAAAGCTTGAAACCGCAGTCAATGCAGAGCAGGAAGCACTGCTTGCCCGAATGGGA
ACATTGCAAGAACGCTTGGAGTATTTCGACTTCTATGAGGCAGAAACAATTCTGTTGGAGTTTGCAGATAAAATGAGCATTGATGCAGAA
TTATATCATCGTCCGATGAGAGAGCTTTCAGGCGGACAAAAATCCAAAATGGCATTTGCCAGACTACTATATTCAAAACCGGAAATTCTA
TTGTTGGATGAGCCTACCAACCATTTAGATGTCAGCACAAAGGATTTTGTTATAAAATACTTAAAGAATTATAGGGGTTCGGTACTGATT
ATCAGCCATGATATTGATTTTCTAAATCGGATTATCAACAAAATTATGTACATCAACAAAGCTACCCATAAAATATCTGTTTATGATGGA
GACTACTACATCTACAAGAAAAAGTATGCAGAGGAACAGCGGATTCGTGAAATGGCGATTGTACAGCAGGAAAAAGAAATAAAGGAGCTT
TCCGATTTTGTACAAAAAGCAAAACAAGCCAGTCAGACCAATCATCACCTCAAACGAATGGGTCAAGAGCGAGCCTTGCGGCTTGATAAA
AAGCGTGGAGAGCTGCAAAAGAGAAATCGACTGTACAAGCGTGTGAAGATGGATATTCGCCCCAAGCGTGAAGGGGCACAAGTTCCCTTA
GAGGTGGAAAATATCACCTTCCACTATTCGGGGTATCCCACCCTTTATCAGAACCTTTCCTTTCAGATTAACGGAAGAGAACGATTTCTT
GTGGTGGGTGAAAACGGTGTCGGTAAATCCACCTTATTGAAATTGATGATGGGTATTCTCAGTCCAGATGAAGGATGCATTCGCTTTAAC
CAGAAAACTGATATTGCATATTATGCACAGGAACTCGAACAGCTTGATGAAAACAAAACGGTCATTGACAATGTGGAGTCTGAAGGATAT
ACACCGTGGCAAATCAGAGCCGTACTGAGCAACTTCCTGTTTTATGATGACGATGTAAACAAGAAAGTATCTGTGCTGTCCCCTGGAGAA
AAAGCAAGGGTTGCCCTTTGCAAAATCCTATTACAGAAAGCCAATCTTTTGATACTGGACGAGCCGACCAACCACCTTGACCCAGAAACG
CAGAAAATCATTGGCGGCAACTTCAATTTGTTTGAGGGAACCATTATTGCCGTTAGCCATAACCCATCCTTTGTGGAACAAATCGGAATT
AGCCGTATGCTTATTTTGCCCAGCGGTCGAATTGAACCCTATTCCCGTGAGCTGCTTGAGTATTATTATGAAATCAACGGTTCTGTTGCA
AAGTTTTAA