ABC-F ATP-binding cassette ribosomal protection protein [AMR Gene Family]

Accession ARO:3004469
DefinitionA subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins.
Drug Classmacrolide antibiotic, lincosamide antibiotic, streptogramin antibiotic, tetracycline antibiotic, oxazolidinone antibiotic, phenicol antibiotic, pleuromutilin antibiotic
Resistance Mechanismantibiotic target protection
Classification5 ontology terms | Show
Parent Term(s)8 ontology terms | Show
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
+ confers_resistance_to_drug_class lincosamide antibiotic [Drug Class]
+ confers_resistance_to_drug_class streptogramin antibiotic [Drug Class]
+ confers_resistance_to_drug_class tetracycline antibiotic [Drug Class]
+ confers_resistance_to_drug_class oxazolidinone antibiotic [Drug Class]
+ antibiotic target protection protein
+ confers_resistance_to_drug_class phenicol antibiotic [Drug Class]
+ confers_resistance_to_drug_class pleuromutilin antibiotic [Drug Class]
14 ontology terms | Show

Sharkey LKR, et al. 2018. ACS Infect Dis 4(3):239-246 Antibiotic Resistance ABC-F Proteins: Bringing Target Protection into the Limelight. (PMID 29376318)

Sharkey LK, et al. 2016. MBio 7(2):e01975 ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection. (PMID 27006457)