oxazolidinone antibiotic [Drug Class]

Accession ARO:3000079
DefinitionOxazolidinones are a class of synthetic antibiotics discovered the the 1980's. They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. Linezolid is the only member of this class currently in clinical use.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
9 ontology terms | Show
+ linezolid [Antibiotic]
+ tedizolid [Antibiotic]
+ contezolid [Antibiotic]
+ TBI-223 [Antibiotic]
+ 50S ribosomal subunit P-site targeted_by
+ 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics [AMR Gene Family] confers_resistance_to_drug_class
+ 23S rRNA with mutation conferring resistance to linezolid antibiotics [AMR Gene Family] confers_resistance_to_drug_class
+ Cfr 23S ribosomal RNA methyltransferase [AMR Gene Family] confers_resistance_to_drug_class
+ mlaFEDB confers_resistance_to_drug_class

Wilson DN, et al. 2008. Proc Natl Acad Sci U S A 105(36): 13339-13344. The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning. (PMID 18757750)